16 results
Acute-on-Chronic Liver Failure (ACLF) Clinical Guidelines

ACLF = possibly reversible condition in those with CLD (± cirrhosis)
Acute-on-Chronic ... those with CLD (± cirrhosis ... months without treatment ... Drug-Induced Liver Injury ... #management #diagnosis
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework
Mild (<100-500): 
 • NAFLD
 • Cirrhosis
 •
- Differential Diagnosis ... • NAFLD • Cirrhosis ... • Chronic Viral ... Drug-induced liver injury ... #hepatology #transaminitis
Patterns of Liver Injury
Transaminase Levels:
  > 50x normal - Ischemic Hepatitis
  > 20x normal
Patterns of Liver Injury ... CMV), Alcoholic cirrhosis ... 5-10x normal - Chronic ... #hepatology #LFTs ... #differential #diagnosis
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm
DILI suspicion
Features toxic aetiology: Skin involvement, Kidney injury,
DILI) - Stepwise Diagnosis ... non-essential drug/HDS treatments ... e.g. ascites), Chronic ... #Diagnosis #Algorithm ... #hepatology
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
disequilibrium syndrome • Diagnosis ... , chronic kidney ... , and chronic kidney ... Tolvaptan) • Treatment ... #Medications #Table
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
- Differential Diagnosis ... > 2 • NASH, Chronic ... hepatitis: < 1 • Cirrhosis ... : > 3 • Chronic ... #differential #diagnosis
Chronic Hepatitis B - Diagnosis and Management Algorithm

• Who to treat: Essentially treat the pts with
B - Diagnosis and ... viremia or have cirrhosis ... HBV #Algorithm #Diagnosis ... #Management #Treatment ... #Hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
> 2 • NASH, Chronic ... hepatitis: < 1 • Cirrhosis ... : > 3 • Chronic ... liver #chemistry #diagnosis ... #differential #Hepatology
Hepatic Encephalopathy - Diagnosis and Management Summary
Definition:
 • Alteration in brain function manifested by neuropsychiatric symptoms
Prevalence: At cirrhosis ... noxious stimuli) TREATMENT ... Initiate empiric treatment ... #Management #treatment ... #hepatology
Autoimmune Hepatitis

Clinical Presentation
 - Highly variable clinical presentation, from subclinical disease to acute liver failure.
 -
- Symptoms of chronic ... pattern of liver injury ... , AIH diagnosis ... regarding need for treatment ... #Management #Hepatology