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management hemophagocytic hlh lymphohistiocytosis b12 cobalamin deficiency differential essential et hemeonc mds myelodysplasia myelodysplastic oncology rheumatology summary syndromes thrombocythemia thrombocytosis
Causes of Thrombocytosis - Differential Diagnosis Algorithm Spurious: • Artifact (redo CBC) Autonomous: • Essential thrombocytosis • Polycythemia
Causes of Thrombocytosis ... Algorithm Spurious ... Artifact (redo CBC ... effect following treatment ... #Algorithm #Causes
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... →Activation of CD8 ... Treatment: • ... #management #treatment ... #summary #rheumatology
Vitamin B12 (Cobalamin) Deficiency Etiology: • Vit B12 - aka cobalamin. Present in foods derived from animal
• Common Causes ... large total body stores ... • Labs: - CBC ... Check for IF ab Treatment ... #management #nutrition
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Pinpoint-sized red spots ... skin that are caused ... Platelet Disorders • Nutritional ... Myelodysplastic #Syndromes #diagnosis ... #hematology #oncology
Essential Thrombocythemia (ET) ET is a chronic myeloproliferative neoplasm. Most cases are related to mutations that affect
Most cases are related ... : On the CBC, ... • Treatment algorithms ... Thrombocythemia #ET #hematology ... #hematology
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
hyperinflammatory syndrome caused ... Pathophysiology ... of NK cells and CD8 ... Treatment Approach ... #Management #Hematology
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