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diagnosis hematology hemophagocytic hlh treatment vasculitis activation common cvid differential hemeonc hodgkins hypogammaglobulinemia igg4 immunodeficiency immunology lymphoma macrophage mas oncology
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
Classification of ... - Kawasaki disease ... - Wegener granulomatosis ... dermatomyositis #Size #Classification ... Vessels #Diagnosis #Rheumatology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Malabsorption • Granulomatous ... breast cancer Granulomatous ... and M panel Management ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH) Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Hemophagocytic Lymphohistiocytosis ... • Autoimmune diseases ... Adult-onset Still disease ... #diagnosis #management ... treatment #summary #rheumatology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
haemophagocytic lymphohistiocytosis ... hemophagocytic lymphohistiocytosis ... highly inflammatory disease ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Hemophagocytic Lymphohistiocytosis ... age, however the disease ... Hemophagocytic #Lymphohistiocytosis ... #diagnosis #management ... #treatment #hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
glomerulonephritis - Granulomatous ... VESSEL VASCULITIS (Granulomatous ... disease): • Takayasu ... differential #diagnosis #rheumatology ... #classification
Hemophagocytic Lymphohistiocytosis (HLH) Treatment Primary HLH: - HLH-94 Protocol • Dexamethasone
Hemophagocytic Lymphohistiocytosis ... or autoimmune disease ... for refractory disease ... HLH #Treatment #management ... #hematology
IGG-4 RELATED DISEASE WHAT? • A chronic, immune-mediated fibroinflammatory disease with tumefactive infiltration of IgG4+ plasma cells
IGG-4 RELATED DISEASE ... complement • Classification ... mimics excluded MANAGEMENT ... IGG4 #Diagnosis #Management ... #Rheumatology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
-95% of cases) Classification ... number of sites of disease ... lymphoma #diagnosis #classification ... #hematology #oncology ... #management
Hemophagocytic Lymphohistiocytosis (HLH) High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
Hemophagocytic Lymphohistiocytosis ... recognition and management ... ▪ Autoimmune diseases ... Hemophagocytic #Lymphohistiocytosis ... #Hematology #HemeOnc
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