14 results
Proposed Treatment Algorithm for MAS / HLH

#MAS #HLH #Hemophagocytic #Lymphohistiocytosis #Management #Treatment #Algorithm #Hematology
Algorithm for MAS / HLH ... #MAS #HLH #Hemophagocytic ... #Lymphohistiocytosis ... #Management #Treatment ... #Algorithm #Hematology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Hemophagocytic Lymphohistiocytosis ... • Autoimmune diseases ... Adult-onset Still disease ... #diagnosis #management ... treatment #summary #rheumatology
Hemophagocytic Lymphohistiocytosis (HLH)
Definition: Overwhelming clinical syndrome associated with excessive macrophage activation and cytokine storm due to
Hemophagocytic Lymphohistiocytosis ... age, however the disease ... Hemophagocytic #Lymphohistiocytosis ... #diagnosis #management ... #treatment #hematology
Macrophage Activation Syndrome (MAS)
Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH)

What?
A subset of
haemophagocytic lymphohistiocytosis ... hemophagocytic lymphohistiocytosis ... (HLH) that develops ... Syndrome #Diagnosis #Management ... #Hematology #Rheumatology
Hemophagocytic Lymphohistiocytosis (HLH) Treatment
Primary HLH:
 - HLH-94 Protocol
    • Dexamethasone
Hemophagocytic Lymphohistiocytosis ... or autoimmune disease ... for refractory disease ... Hemophagocytic #Lymphohistiocytosis ... #management #hematology
Classification of Vasculitis 
Vasculitis of large vessels 
 - Arteritis temporalis (giant-cell arteritis) 
 - Takayasu
Classification of ... - Kawasaki disease ... - Wegener granulomatosis ... dermatomyositis #Size #Classification ... Vessels #Diagnosis #Rheumatology
Common Variable Immunodeficiency (CVID)

What?
CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Malabsorption • Granulomatous ... breast cancer Granulomatous ... and M panel Management ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Hemophagocytic Lymphohistiocytosis (HLH)

High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
Hemophagocytic Lymphohistiocytosis ... recognition and management ... ▪ Autoimmune diseases ... #Lymphohistiocytosis ... #Hematology #HemeOnc
Hodgkin's Lymphoma Overview

Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
-95% of cases) Classification ... number of sites of disease ... lymphoma #diagnosis #classification ... #hematology #oncology ... #management
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
glomerulonephritis - Granulomatous ... VESSEL VASCULITIS (Granulomatous ... disease): • Takayasu ... differential #diagnosis #rheumatology ... #classification