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rheumatology dermatology algorithm management rash acute aki arteritis classification clinical conditions cutaneous dermatologic dermpath extrarticular giantcell globulin glomerulonephritis gpa granulomatosis
Dermatological semiology of Cutaneous Vasculitis Clinicopathologic correlations • Purpura, papules, pustules, necrosis: involvement of small vessels
Identification of causes ... (5%): PAN > GPA ... #semiology #signs ... #lesions #diagnosis ... pathology #lesions #differential
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... ANCA (C-ANCA): GPA ... eGPA, MPA >>> GPA ... #differential # ... diagnosis #algorithm
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Diagnosis Framework ... - GPA - EGPA ... Vasculopathy #Purpura #Differential ... #Diagnosis #hematology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Polyangiitis (GPA ... polyangiitis (GPA ... GPA causes disease ... Diagnosis: Vasculitis ... #diagnosis #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
> PR3 60% • GPA ... tract, and often causes ... purpura: strong sign ... • ANCA (Dx: GPA ... differential #diagnosis
Acute Kidney Injury - AKI Workup Algorithm and Differential Diagnosis Baseline Investigations: full blood count with differential,
Diagnosis Baseline ... clinical context and signs ... Glomerulonephritis / Vasculits ... ANCA, ANA, Anti-GBM ... #causes
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
systemic sx + signs ... very remarkable w/differential ... diagnosis = vasculitis ... (Cornelia NEJM ... #Temporal #Signs
Causes of Petechial Rash - Differential Diagnosis Algorithm Pinpoint areas (less than 2 mm) of hemorrhage, which
Causes of Petechial ... Rash - Differential ... RA, Sjogren's, GPA ... deficiency Work ... #Causes #dermatology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
Autoimmune ANCA vasculitis ... (AAV): GPA (granulomatous ... subglottic stenosis) in GPA ... mononeuritis multiplex WORKUP ... Goodpasture's cause
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... Differential Diagnosis ... purpura: Strong sign ... MPO > PR3 60/ GPA ... Diagnosis #Rheumatology
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