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Algorithm for Diagnosis of the Vesiculobullous Rash

Febrile, Diffuse Distribution:
 - Varicella,  Smallpox,  Disseminated, Gonococcal,
Vesiculobullous Rash ... DIC Febrile Localised ... Afebrile, Localised ... Vesiculobullous #Vesicular #Rash
Vesiculobullous Rashes - THE ALGORITHMIC APPROACH 
Vesiculobullous rashes provoke significant angst
in many physicians (Figure 5, page
noting whether the rash ... is diffuse or localized ... vesiculobullous rash ... disease present with localized ... afebrile with a localized
Multiple scattered erythematous papules with multiple surrounding excoriations and hemorrhagic crusts, mostly localized to extremities but
crusts, mostly localized ... #Dermatology #Rash
Multiple scattered erythematous papules with multiple surrounding excoriations and hemorrhagic crusts, mostly localized to extremities but
crusts, mostly localized ... #Dermatology #Rash
Lupus (SLE): Mucocutaneous Manifestations

 • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
release cytokines -> localized ... plugging -> Discoid Rash ... Malar (butterfly) Rash
Erythemas Summarized
Erythema ab igne
 • A dermatosis that results from repeated exposure to heat (fires, heating
Rash is usually ... Lyme in early localized ... Fever + facial rash ... • Evanescent rash ... Acute systemic rash
Lyme Disease - Diagnosis and Management Summary

Lyme Disease Epidemiology:
- Spirochete
- Reservoir: small mammals & birds
- Transmitted
Early Localized ... Rash: distinctive
Pustular Skin Lesions - Differential Diagnosis Framework

What are pustules?
• Pustules < 5-10 mm + pus
• Material
disease Pustular Localised ... Generalized itchy rash
Varicella Zoster Virus (VZV) - Post-Exposure Prophylaxis
Varicella or Disseminated Zoster:
 • Transmission: direct contact w/ fluid
Timeline: 1-2d pre rash ... lesions crusted Localized
Skin Hypopigmentation - Differential Diagnosis Algorithm

Diffuse Congenital - Generalized hypopigmentation of hair, eyes, skin
 • Phenylketonuria
• Vitiligo Localized ... sclerosis (white "ash ... leaf" macules) Localized