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cardiology hfref management chf guideline failure heart im nejm pathophysiology resistance acei angiotensinreceptorblockers angiotensinreceptorneprilysininhibitor arb bumetanide cardiomyopathy carvedilol ckd diagnosis
Guidelines Directed medical therapy for Heart Failure Satyendra Dhar, MD, @DharSaty #HFrEF #GDMT #sodium-glucosecotransporter-2inhibitors #SGLT2i #reninangiotensinaldosteronesysteminhibitors
DharSaty #HFrEF #GDMT ... angiotensinreceptorblockers #ARB #ARNI ... MineralocorticoidReceptorAntagonist #LoopDiuretic
Nephron Remodeling as a Mechanism of Diuretic Resistance. When high doses of loop diuretics are used
Nephron Remodeling ... basis, the distal nephron ... of the distal nephron ... Pathophysiology #Nephro ... #IM #LoopDiuretic
Heart Failure with Reduced Ejection Fraction (HFrEF) - Guideline Directed Medical Therapy - Initiation Strategies •
Approach: ACE, ARB, ARNI ... -2 Inhibitor → ARNI ... Guideline #management #GDMT
Heart Failure with Reduced Ejection Fraction (HFrEF) - Guideline Directed Medical Therapy • Beta-blocker • ACE,
• ACE, ARB, ARNI ... Guideline #management #GDMT
HFrEF: Guideline Directed Medical Therapy "Must Be On" • ACEI, ARB, or ARNI AND select Beta Blockers
ACEI, ARB, or ARNI ... ACEI or ARB • ARNI ... chf #cardiology #GDMT
Mechanisms of Loop Diuretic Action and Resistance. Panel A, loop diuretics circulate bound to protein. As
Pathophysiology #Nephro ... #IM #LoopDiuretic
Guideline-Directed Medical Therapy (GDMT) in HFrEF and CKD • Class I pillars of HFrEF GDMT across
Medical Therapy (GDMT ... pillars of HFrEF GDMT ... disease: ACEI, ARB, ARNI ... after core GDMT ... part of HFrEF GDMT
Peripartum Cardiomyopathy - Summary 1. Definition • Towards the end of pregnancy to 5 months postpartum
Avoid ARB/ACE-I/ARNI ... pregnancy, teratogenic GDMT
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