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management differential algorithm coagulation treatment abnormal anesthesia anesthesiology checklist disorders hypercoagulable intraoperative prolonged pt renal syndrome amyloid amyloidosis antiphospholipid apls
Approach to the Hypercoagulable State Arterial thromboembolism → Cardiac rhythm monitoring, Echocardiogram, Vascular imaging → Test for APS, particularly
rhythm monitoring, Echocardiogram ... • Provoked (e.g ... screening, CBC, aPTT ... #hematology #diagnosis ... #algorithm #hematology
Chest Pain - Diagnosis and Workup Algorithm History and Exam Acute life-threatening causes: • Acute myocardial infarction •
Chest Pain - Diagnosis ... life-threatening causes ... : • EKG • Bedside ... LET, lipase, PT. aPTT ... • Serial troponin
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... and Workup History ... : INR/PT, aPTT(liver ... #Causes #Workup ... #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... Prolonged Activated Partial ... Pre-analytical cause ... #diagnosis #differential ... #hematology #coagulation
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... Prolonged PT and aPTT ... the PT and the aPTT ... #diagnosis #differential ... #hematology #coagulation
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
evaluation or workup ... 1,500 cells/µL Workup ... signs or symptoms (eg ... #Differential #diagnosis ... #hematology #eosinophilia
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
established disease) • aPTT ... mixing study (aPTT ... normal in mild cases ... hemophilia type (e.g ... Management #treatment #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
Treat primary cause ... INR < 2.3 - APTT ... #Coagulation #diagnosis ... #causes #treatment ... #management #hematology
Intraoperative Sepsis - Guidelines for Crises in Anaesthesia Severe sepsis (hypotension persisting after initial fluid challenge of
likely underlying cause ... cultures if possible (eg ... ongoing management plan ... Intraoperative #Checklist #Diagnosis ... #Management #Workup
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
activity is the diagnostic ... available for rapid diagnosis ... performed PT, PTT ... decrease in most cases ... #Workup #Hematology
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