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diagnosis dermatology differential management antimda5 antimda5dm antinxp2 antinxp2dm autoimmune cold druginduced hematology inflammatory lupus myopathies myopathy myositis reactions sle taco
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
Inflammatory Myopathies Dermatomyositis ... Subacute • Pattern: Proximal ... differential #diagnosis #comparison ... #rheumatology # ... table
ANTI-MDA5 DERMATOMYOSITIS Cutaneous manifestations: • Periorbital heliotrope (blue-purple) rash with edema • Erythematous rash on the face, or the
ANTI-MDA5 DERMATOMYOSITIS ... auricular papules Clinical ... Men • ~50% of cases ... vasculopathies • Proximal ... #rheumatology #
Cold Urticaria Prevalence - 0.05% in the population Disease onset - Mostly 2nd to 4th decades of life Causes
decades of life Causes ... and clinical associations ... fever, fatigue, Nausea ... Urticaria #diagnosis #rheumatology ... #comparison #table
TRALI vs TACO - Transfusion Reactions TRALI: • Epidemiology: 0.1% of transfused patientsl • Risk factors: Critical
Risk factors: Critical ... without other cause ... Transfusion #Reactions #hematology ... #diagnosis #comparison ... #table
Drug Induced Lupus vs SLE Drug Induced Lupus (DIL): • Epidemiology: -10% of all lupus cases, drug-dependent,
to 1:1 F:M • Clinical ... Discontinuation of causal ... 40, F:M 9:1 • Clinical ... druginduced #lupus #sle #comparison ... #table #rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Commonly symmetric proximal ... RP-ILD), dermato-rheumatologic ... statins - probably caused ... Signal recognition particles ... Myositis #Myopathy #rheumatology
Anti-NXP-2 Dermatomyositis What? DM with generalized subcutaneous edema Pts have more myalgias, more severe weakness, and an increased prevalence
Anti-NXP-2 Dermatomyositis ... Progressive myalgia • Proximal ... auricular papules Clinical ... Muscle atrophy may cause ... diagnosis #management #rheumatology
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