24 results
Dyspnea - Differential Diagnosis Framework

Cardiovascular Causes of Dyspnea:
 • Myocardium:
	- Heart failure
	- CAD/ACS
	- Valvulopathy
 • Electrical:
	-
- Tamponade Pulmonary ... - Asthma - COPD ... HTN - Vasculitis ... Transverse myelitis • Hematology ... : - Anemia
Hemolytic Anemia - Differential Diagnosis Algorithm
 • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... Differential Diagnosis Algorithm ... Agglutination - Cold ... cardiac valve, vasculitis ... #workup #hematology
Approach to Thrombocytosis - Elevated Platelet Count - Differential Diagnosis Algorithm

Peripheral Smear concerning for malignancy?
→ Refer to hematology ... hemolysis, deficiency anemia ... , Vasculitides, ... IBD, Celiac disease ... #hematology
Peripheral Blood Smear Analysis
Hypochromia
Megaloblastic Anemia
Schistocytes: Microangiopathic hemolytic anemia (e.g. DIC, TTP, HUS)
Microspherocytes: Autoimmune hemolytic anemia
Sickled red
cells: Sickle cell disease ... Alcohol abuse, Heavy metal ... Smear #Analysis #hematology ... interpretation #clinical ... #anemia
Cold Agglutinin Disease

3 Types of Cold Sensitive Antibodies:
  1. Cold Agglutinins (CAD)
  2. Donath-Landsteiner
Cryoglobulins (Vasculitic ... Viral Infection Clinical ... • Symptoms of anemia ... • hemolytic anemia ... #hematology #diagnosis
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
progressing GN • New pulmonary ... glomerulonephritis and/or pulmonary ... + MPO-ANCA MEDIUM ... aortic aneurysm • Medium ... differential #diagnosis #rheumatology
Iron Deficiency Anemia - Differential Diagnosis Algorithm

Labs: Ferritin, iron, transferrin, TIBC, TSAT, sTfR

 • Blood loss:
Iron Deficiency Anemia ... Differential Diagnosis Algorithm ... athletic training, Pulmonary ... Structural: Celiac disease ... #ferritin #hematology
Clinical Classification of Pulmonary Hypertension

1. Pulmonary arterial hypertension from pulmonary vasculopathy
Idiopathic pulmonary arterial hypertension
Heritable gene mutations
Clinical Classification ... Chronic hemolytic anemia ... pulmonary disease ... multifactorial mechanisms Hematologic ... neurofibromatosis, vasculitis
Cryofibrinogenemia Summary

Cryofibrinogenemia Epidemiology:
 • 40-70 years with a modest female predominance

Cryofibrinogenemia:
 • The precipitation of a
malignancies, vasculitis ... thrombophlebitis, pulmonary ... Occlusion of small to medium-sized ... Cryofibrinogenemia #diagnosis #rheumatology ... #hematology
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome
Clinical Syndrome:
 • Common Clinical Features: alveolitis, ear and
Somatic) Syndrome Clinical ... thromboembolic disease ... recurrent fevers, vasculitis ... Abnormalities: macrocytic anemia ... Autoinflammatory #Somatic #rheumatology