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differential hematology leukemia vasculitis ana antibodies antinuclear autoimmune behcet chronic classification cll disease endocarditis erythematosus infective lupus lymphocytic management marantic
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Systemic Lupus (SLE ... Demyelinating syndromes ... erythematosus #signs ... #symptoms #diagnosis ... #rheumatology
Autoimmune Myositis Necrotizing myopathy is associated with higher CK levels, greater level of muscle weakness, less systemic
less systemic symptoms ... , holster sign, ... anti-synthetase syndrome ... Can also see mechanics ... #rheumatology
Behçet's Syndrome Systemic disease associated with inflammation of multiple organs, small-vessel vasculitis and large-vessel vasculopathy Epidemiology: • Young
Medium and large ... Oral aphthae : SLE ... • Arthritis: SLE ... #signs #symptoms ... #rheumatology #
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
microscopy and serial ... context of other symptoms ... ), Sjogren's Syndrome ... ANA #patterns #rheumatology ... #diagnosis #differential
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
non-Hodgkin lymphoma SLL ... with no early symptoms ... Physical Exam/Signs ... #workup #oncology ... #hematology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
rapid onset of symptoms ... develop leukostasis syndrome ... • Tumor lysis syndrome ... #Leukemia #Hematology ... #Oncology #Diagnosis
Differentiating NBTE from Infective Endocarditis No pathognomonic signs/symptoms or echo features that are specific to NBTE, and
pathognomonic signs ... /symptoms or echo ... conditions: Autoimmune (SLE ... cultures/serology: Serial ... #Endocarditis #comparison
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
+ MPO-ANCA MEDIUM ... Presentation - Systemic Symptoms ... purpura: strong sign ... vasculitis, and SLE ... #rheumatology #
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
Myelodysplastic Syndromes ... age 70 years Symptoms ... Exposure to heavy metal ... #diagnosis #hematology ... #oncology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
diseases, such as SLE ... purpura: Strong sign ... primary condition MEDIUM ... • Progressive symptoms ... #Rheumatology
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