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Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS Laboratory TLS: • Uric
Uric acid ≥ 8.0 mg ... ≥ 6.0 mEq/dL ... Phosphorus ≥ 4.6 mg ... ≤ 7.0 mg/dL Clinical ... Syndrome #TLS #diagnosis
Tumor Lysis Syndrome - Workup and Management Initial workup: BMP, Serum uric acid, LDH, Urine output, Consider
Uric acid ≥ 8 mg ... /dL • Potassium ... ≤ 7 mg/dL • OR ... Treatment of Clinical ... Lysis #Syndrome #diagnosis
Liver Disease in Pregnancy Intrahepatic Cholestasis of Pregnancy (ICP) • Onset/Trimester: 25-32 weeks • Typical clinical features:
Bilirubin: <5 mg ... /dL • Hepatic ... Bilirubin: <5 mg ... /dL unless massive ... #differential #diagnosis
Clinical Diagnosis of Autoimmune Hepatitis - Onset of jaundice within prior 8 weeks - Ongoing consumption
Clinical Diagnosis ... bilirubin >3.0 mg ... /dL Potential confounding ... Autoimmune #Hepatitis #Diagnosis
Clinical diagnosis of Alcoholic Hepatitis (AH) • Onset of jaundice within prior 8 weeks • Ongoing
Clinical diagnosis ... bilirubin >3.0 mg ... /dL Potential confounding ... #diagnosis #Alcoholic
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
as jaundice on clinical ... than 20 to 50 mg ... /dL. ... /dL • CN syndrome ... bilirubin #hepatology #diagnosis
Hypertensive Disorders of Pregnancy Chronic Hypertension: • Guidelines as SBP ≥130 or DBP ≥ 90 mmHg •
• First diagnosed ... Proteinuria (e.g., 300 mg ... insufficiency (Cr > 1.1 mg ... /dL or doubling ... so have high clinical
CNS Infections - Viral Encephalitis and Bacterial Meningitis - Differential Diagnosis Framework Viral Encephalitis: MCC: Enteroviruses (e.g., coxsackievirus
- Differential Diagnosis ... • Common clinical ... level 100-500 mg ... /dL • Glucose ... level: <40 mg/dL
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
late adulthood • Diagnosis ... to 8 years Clinical ... conditions Diagnosis ... than 100 to 300 mg ... /dL) • Low serum
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
PRES) Overview Clinico-Radiological ... brain PRES Clinical ... PRES-Associated Clinical ... level (mean 58 mg ... /dL in one study
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