29 results
Hypermagnesemia - Etiologies by Mechanism
Renal Failure 
Excessive Mg Administration 
 - Massive PO intake
Failure Excessive Mg ... intake - Magnesium ... - Excessive IV Mg ... - Tumor lysis syndrome ... Diagnosis #High #Magnesium
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS
Laboratory TLS:
 • Uric
of Tumor Lysis Syndrome ... Uric acid ≥ 8.0 mg ... Phosphorus ≥ 4.6 mg ... ≤ 7.0 mg/dL Clinical ... #TumorLysis #Syndrome
Hypomagnesemia Treatment Protocol - Magnesium Repletion
Goal serum magnesium concentration 2.0-2.4 mg/dL
Serum magnesium concentration - IV Magnesium
/dL Serum magnesium ... /dL - 2g IV • ... 1.0-1.5 mg/dL - ... IV • < 1.0 mg ... /dL - 6g IV
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
- calcium > 11 mg ... /dL / >1 mg/dL the ... disease - Cr >2 mg ... /dL or CC < 40 ml ... plasmacytoma, POEMs syndrome
Tumor Lysis Syndrome - Workup and Management

Initial workup: BMP, Serum uric acid, LDH, Urine output, Consider
Tumor Lysis Syndrome ... Uric acid ≥ 8 mg ... /dL • Potassium ... ≤ 7 mg/dL • OR ... #Tumor #Lysis #Syndrome
Gestational Hypertension & Preeclampsia

Gestational Hypertension (gHTN) 
• BP > 140/90 
• Onset > 20 wks gestation
Proteinuria (300 mg ... ) • Cr > 1.1 mg ... /dL or 2x • Thrombocytopenia ... Seizure HELLP Syndrome
Hypomagnesemia - Etiologies by Mechanism

Decreased GI Uptake 
 - Poor dietary intake (particularly common in alcoholics)
Familial renal Mg ... wasting syndromes ... - Gitelman syndrome ... - Hungry bones syndrome ... Diagnosis #Low #Magnesium
Causes of Hypomagnesemia - Differential Diagnosis Algorithm
GI LOSS - FeMg < 2-2.5% or 24h Urine Mg
2.5% or 24h Urine Mg ... 2.5% or 24h Urine Mg ... • Gitelman's syndrome ... Hypomagnesemia #Magnesium
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
Bilirubin: <5 mg ... /dL • Hepatic ... necrosis HELLP Syndrome ... Bilirubin: <5 mg ... /dL unless massive
Electrolyte Repletion

Significant electrolyte depletion can result in serious complications. These guidelines are meant to assist with
/L Goal serum magnesium ... concentration 2.0 – 2.4 mg ... /dL Goal serum ... concentration 2.7 – 4.6 mg ... /dL IV electrolyte