46 results
Classification of Tumor Lysis Syndrome (TLS) and Treatment of Metabolic Abnormalities of TLS
Laboratory TLS:
 • Uric
of Tumor Lysis Syndrome ... Uric acid ≥ 8.0 mg ... Phosphorus ≥ 4.6 mg ... ≤ 7.0 mg/dL Clinical ... #TumorLysis #Syndrome
Multiple Myeloma and Monoclonal Gammopathies
C - HyperCalcemia- calcium > 11 mg/dL / >1 mg/dL the ULN
R
- calcium > 11 mg ... /dL / >1 mg/dL the ... disease - Cr >2 mg ... /dL or CC < 40 ml ... plasmacytoma, POEMs syndrome
Tumor Lysis Syndrome - Workup and Management

Initial workup: BMP, Serum uric acid, LDH, Urine output, Consider
Tumor Lysis Syndrome ... Uric acid ≥ 8 mg ... /dL • Potassium ... ≤ 7 mg/dL • OR ... #Tumor #Lysis #Syndrome
Hypomagnesemia (Serum level < 1.7 mg/dL)
Neuromuscular manifestations 
 • Tremor, tetany, seizures 
 • Weakness
Serum level < 1.7 mg ... /dL) Neuromuscular ... Hypomagnesemia #Signs
Diabetes Insipidus vs Syndrome of Inappropriate ADH (SIADH) - Comparison Table

Diabetes Insipidus - Inadequate ADH
SIADH -
Diabetes Insipidus vs Syndrome ... ) - Comparison Table ... SIADH #Comparison #Table ... Pathophysiology #Signs
Gestational Hypertension & Preeclampsia

Gestational Hypertension (gHTN) 
• BP > 140/90 
• Onset > 20 wks gestation
Proteinuria (300 mg ... ) • Cr > 1.1 mg ... /dL or 2x • Thrombocytopenia ... Seizure HELLP Syndrome
Signs and Symptoms of Toxidromes

Sympathomimetic / GABAergic withdrawal 
Cholinergic 
Anticholinergic 
Opioid withdrawal 
Neuroleptic malignant syndrome 
Serotonin
Signs and Symptoms ... Neuroleptic malignant syndrome ... Serotonin syndrome ... Toxidromes #Comparison #Table
Liver Disease in Pregnancy
Intrahepatic Cholestasis of Pregnancy (ICP)
 • Onset/Trimester: 25-32 weeks
 • Typical clinical features:
Bilirubin: <5 mg ... /dL • Hepatic ... necrosis HELLP Syndrome ... Bilirubin: <5 mg ... /dL unless massive
Compelling and Possible Contraindications to Antihypertensive Drugs
Diuretics (thiazides)
 - Gout
 - Metabolic syndrome, Glucose intolerance, Pregnancy,
- Metabolic syndrome ... creatinine >2.5 mg ... /dl„ in men, >2.0 ... mg/dL in women) ... contraindications #table
Hypermagnesemia - Etiologies by Mechanism
Renal Failure 
Excessive Mg Administration 
 - Massive PO intake
Failure Excessive Mg ... - Excessive IV Mg ... - Tumor lysis syndrome ... High #Magnesium #Table