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differential anemia causes approach arthritis bloodcell cell chronic daytime electrophoresis eosinophil eosinophilia excessive hemolytic indications joint macrocytic microcytic microscopy msk
Causes of Excessive Daytime Sleepiness - Differential Diagnosis Algorithm Insufficient Sleep • Poor Sleep Hygiene • Insomnia
- Differential Diagnosis ... Algorithm Insufficient ... Shift Work) Sleep ... Excessive #Daytime #Fatigue ... #Algorithm #Causes
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
- Differential Diagnosis ... Algorithm Endocrine ... Neoplastic / Hematologic ... • Drug Abuse (e.g ... • Somatization Disorder
Eosinophil Disorders Testing Algorithm INDICATIONS FOR TESTING: • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... Testing Algorithm ... evaluation or workup ... signs or symptoms (eg ... #diagnosis #hematology
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Chemotherapy (e.g ... Unstable hemoglobin disorders ... #differential #diagnosis ... #hematology #microscopy ... #atlas #nomenclature
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Algorithm • Sickle ... other reproducible morphologic ... Consider RBC membrane disorder ... #Algorithm #workup ... #hematology #testing
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... (BM) ablative disorders ... of substrate (e.g ... #Diagnosis #Workup ... #Hematology #Microcytic
Approach to Joint Pain History: Is the pain from: • Joint • Adjacent bursa • Tendon • Ligament • Bone • Muscle • Referred from
• Weakness • Fatigue ... or longer - Fatigue ... Enthesitis: • Site of pathology ... #approach #workup ... #differential #diagnosis
Indications for Serum Protein Electrophoresis (SPEP) • Suspected multiple myeloma, Waldenström's macroglobulinemia, primary amyloidosis, or related
amyloidosis, or related disorder ... associated weight loss, fatigue ... • Unexplained pathologic ... Electrophoresis #SPEP #Hematology ... #Diagnosis
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
red bone marrow, e.g ... Diagnosis? ... Biopsy: Solitary disorder ... IFE, FLC assay Pathology ... #Workup #Hematology
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