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differential arthritis blood bloodcell cell hemolytic joint macrocytic markers microcytic microscopy nomenclature oncology pain plasmacytoma rbc red rheumatology solitary testing
Blood Disorders - Markers and Differential Diagnosis Algorithm Acute • Myloid (AML) - CD13, CD33, CD34,
Algorithm Acute ... - Abnormal morphology ... Pelger-Huet, Macrocytic anemia ... Amy Chung, MD, MSc ... #hematology #Markers
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Chemotherapy (e.g ... Unstable hemoglobin disorders ... #differential #diagnosis ... #hematology #microscopy ... #atlas #nomenclature
Anemia Diagnostic Algorithm Mean corpuscular (cell) volume (MCV): Average RBC size. Under 80 = microcytic. Between 80-95
Anemia Diagnostic ... (BM) ablative disorders ... of substrate (e.g ... #Algorithm #Diagnosis ... #Workup #Hematology
Hemolytic Anemia - Differential Diagnosis Algorithm • Sickle cells - Consider sickle cell disease (diverse genotypes):
Hemolytic Anemia ... other reproducible morphologic ... Consider RBC membrane disorder ... #Algorithm #workup ... #hematology #testing
Approach to Joint Pain History: Is the pain from: • Joint • Adjacent bursa • Tendon • Ligament • Bone • Muscle • Referred from
Approach to Joint ... Enthesitis: • Site of pathology ... #Joint #Pain #MSK ... approach #workup ... #differential #diagnosis
Solitary Cell Plasmacytoma What? • Plasma cell neoplasms can present as a single lesion (solitary plasmacytoma) • In 3%
red bone marrow, e.g ... Biopsy: Solitary disorder ... • No CRAB - no anemia ... IFE, FLC assay Pathology ... #Workup #Hematology
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