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differential rheumatology dermatology algorithm management erythematosus lupus nomenclature oncology secondary sle allergy alopecia arthritis autoimmune basics bloodcell cerebritis classification cll
Causes of Thrombocytosis - Differential Diagnosis Secondary Thrombocytosis (a.k.a Reactive Thrombocytosis): • Acute infection • Solid organ
Causes of Thrombocytosis ... inflammatory disorders ... (e.g. autoimmune ... Myelodysplastic syndrome ... #Causes #hematology
Nail Disorders secondary to Systemic Diseases Nail Fold Abnormality • SLE • Scleroderma • Dermatomyositis Koilonychia - Spoon-shaped
Nail Disorders secondary ... discoloration) • Chronic ... • Nephrotic syndrome ... #Differential #Diagnosis ... #Algorithm #causes
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Chemotherapy (e.g ... Unstable hemoglobin disorders ... #differential #diagnosis ... #hematology #microscopy ... #atlas #nomenclature
Causes of Fatigue - Differential Diagnosis Algorithm Endocrine • Hypo/Hyperthyroidism • Diabetes • Pituitary Insufficiency • Adrenal
Causes of Fatigue ... Neoplastic / Hematologic ... • Drug Abuse (e.g ... • Somatization Disorder ... Fatigue Syndrome
CNS Manifestations of Systemic Lupus Erythematosus (SLE) Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
Manifestations of Systemic ... Demyelinating Syndrome ... , Seizure disorders ... autoantibodies that will cause ... Lumbar Puncture, EEG
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
activate the immune system ... • They can cause ... Cryoglobulins Cause ... Labs/Diagnosis: ... (e.g. systemic
Approach to Elevated Tryptase - Differential Diagnosis Framework The DDx of elevated tryptase can be broken down
- Differential Diagnosis ... into a 4-pass system ... 2nd pass = Chronic ... Eosinophilic GI Disorders ... cell activation syndrome
Chronic Lymphocytic Leukemia - Summary Cancer affecting lymphocytes/Mature B cell neoplasm • Lymphocytes accumulate in large numbers
Chronic Lymphocytic ... rendering the immune system ... lymphoproliferative disorders ... #workup #oncology ... #hematology
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Immunodeficiency disorder ... Autoimmunity • Chronic ... hemolytic anemia) • Systemic ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology
Polycythemia - Differential Diagnosis Algorithm Polycythemia itself isn’t a diagnosis. Like many things, it is a condition
an underlying cause ... and delta are key ... frequently affected systems ... normal/high - Chronic ... #hematology
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