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differential coagulation disorders platelet prolonged aggregometry algorithm bloodcell chest common dermatology distribution gammopathy hemepath hemophilia laboratory management mgrs mixing monoclonal
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... PT and/or aPTT ... to one factor e.g ... #PT #aPTT #Prolonged ... #Causes #diagnosis
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
PT and the aPTT ... inhibitory drugs (e.g ... specific inhibitor (e.g ... #PT #aPTT #Prolonged ... #Causes #diagnosis
Chest Pain - Diagnosis and Workup Algorithm History and Exam Acute life-threatening causes: • Acute myocardial infarction •
Chest Pain - Diagnosis ... life-threatening causes ... : • EKG • Bedside ... , LET, lipase, PT ... . aPTT • Serial
Mixing Study • Clotting tests can be abnormal due to either a clotting factor deficiency, or
Clotting tests can be abnormal ... factor activity (e.g ... clotting test (e.g ... PT and/or aPTT) ... Mixing #Study #diagnosis
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... and Workup History ... : INR/PT, aPTT(liver ... function test, ANA (e.g ... #Causes #Workup
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
mixing study (aPTT ... mild cases) • ... PT/INR & von Willebrand ... hemophilia type (e.g ... Management #treatment #hematology
Platelet disorders and Aggregometry Glanzmann Thrombasthenia • Defective aggregation to all agonists except ristocetin • Normal platelet,
platelet, PT, PTT ... count and platelet morphology ... considered first-line ... Platelet #disorders #hematology ... #differential #diagnosis
Red Blood Cell (RBC) Morphology Microcytic RBC: Pyridoxine deficiency, Thalassemia, Iron deficiency anemia, Chronic disease anemia (sometimes),
Blood Cell (RBC) Morphology ... Chemotherapy (e.g ... #differential #diagnosis ... #hematology #microscopy ... #atlas #nomenclature
TTP - Laboratory Evaluation for Thrombotic Thrombocytopenic Purpura Activity of von Willebrand factor-cleaving protease activity - A
activity is the diagnostic ... available for rapid diagnosis ... be performed PT ... , PTT, and fibrinogen ... #Workup #Hematology
Common Dermatological Conditions - Distribution and Morphology • Acne vulgaris - Face, upper back, chest -
Distribution and Morphology ... and pruritus (e.g ... honey-colored crusts ... Varies with site, (e.g ... #differential #diagnosis
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