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diagnosis differential neurology rheumatology sle agammaglobulinemia algorithm alzheimersdisease avascularnecrosis centralretinalartery classification complications cord crao crisis dementia dermatology disorders erythematosus extraarticular
Clinical Features of Systemic Lupus (SLE) General: Fever (50%), Depression, Fatigue (75%), Weight loss (50%) Eye: Sjögrens (15%) Skin
Butterfly rash, Vasculitis ... Fits, Hemiplegia, Ataxia ... pain (20%) Renal disease ... erythematosus #signs ... #symptoms #diagnosis
Alzheimer’s Disease: Pathogenesis and Clinical Findings Risk factor for Late Onset Alzheimer's (99% of cases): - Increasing
Alzheimer’s Disease ... Motor dysfunction: myoclonic ... incontinence, apraxia ... AlzheimersDisease #Dementia #pathophysiology ... #symptoms
Lupus (SLE): Mucocutaneous Manifestations • Langerhan cells and keratinocytes release cytokines -> localized inflammatory response ->
hair follicles -> causes ... endothelium) & Decr blood ... Livedo Reticularis, Vasculitis ... #diagnosis #signs ... #symptoms #complications
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... such as systemic lupus ... Presentation - Systemic Symptoms ... purpura: strong sign ... Large Vessel: Blood
Rhombencephalitis BACTERIAL - Listeria (biphasic illness with bulbar dysfunction occurring later) - Mycobacterium tuberculosis - Pneumococcus - Brucella - Borrelia (Lyme Disease) -
Toxoplasmosis AUTOIMMUNE/VASCULITIS ... - Systemic Lupus ... syndrome (bulbar symptoms ... - opsoclonus-myoclonus ... Differential #Diagnosis #Causes
Rheumatoid arthritis (RA): Extra-articular manifestations Skin: • Inflammation of skin (esp. over areas of stress) forms
vessels (vasculitis ... inflammation tends to cause ... interstitial lung disease ... RheumatoidArthritis #RA #pathophysiology ... #signs #symptoms
Features of a Sickle Cell Crisis Sickle-cell disease - an autosomal recessive blood disorder. Characterized by red
Sickle-cell disease ... Sickle cell disease ... The underlying pathophysiology ... Crisis #Features #Signs ... #Symptoms
IgA Vasculitis – Henoch Scholein Purpura: Pathogenesis and Clinical Findings - Infectious Agents - 50% have
endothelial lining of blood ... periumbilical region), nausea ... HenochScholeinPurpura #Pathophysiology ... #Diagnosis #Signs ... #Symptoms
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Presentation: Systemic Symptoms ... purpura: Strong sign ... pulses, bruits, or blood ... • Progressive symptoms ... tract, and often causes
Central Retinal Artery Occlusion: Pathogenesis and clinical findings • Inflammatory Disease: (i.e. GCA, SLE, GPA) ->
• Inflammatory Disease ... retinal edema caused ... Occlusion #CRAO #pathophysiology ... ophthalmology #diagnosis #signs ... #symptoms
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