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diagnosis hematology management classification neurology syndromes vasculitis algorithm alzheimersdisease anemia aplastic apml beriberi cord deficiency dementia differentiation disorders encephalopathy geriatrics
Alzheimer’s Disease: Pathogenesis and Clinical Findings Risk factor for Late Onset Alzheimer's (99% of cases): - Increasing
mutations - Down syndrome ... Motor dysfunction: myoclonic ... incontinence, apraxia ... AlzheimersDisease #Dementia #pathophysiology ... diagnosis #signs #symptoms
Myelodysplastic Syndromes (MDS) What? Myelodysplastic syndromes are a group of disorders caused by blood cells that are poorly
group of disorders caused ... age 70 years Symptoms ... count with differential ... #diagnosis #hematology ... #oncology
Thiamine Deficiency - Differential Diagnosis Framework and Clinical Manifestations Causes of Thiamine Deficiency: • Poor intake: - Diets
Thiamine Deficiency - Differential ... Manifestations Causes ... increase venous blood ... Ophthalmoplegia - Ataxia ... beriberi #nutrition #pathophysiology
Differentiation Syndrome in APML Epidemiology: • Incidence: common in APL (2-48% depending on the study) • Triggers:
Differentiation Syndrome ... ATRA treatment Pathophysiology ... Diagnosis: >3 symptoms ... initiation • Differential ... #oncology
Leukemias Overview: ALL, CML, AML, APML, CLL Acute leukemias > 20% blasts in the peripheral blood smear
-> AML: Blast crises ... develop leukostasis syndrome ... • Tumor lysis syndrome ... #Leukemia #Hematology ... #Oncology #Diagnosis
Spinal Cord Disorders - Differential Diagnosis Framework Spinal cord neurological lesion: Clinical findings: • Symptoms and signs below
Cord Disorders - Differential ... often- Sensory ataxia ... Non-compressive Spinal Cord Causes ... Blockage of the Blood ... MCTD, Sjogren syndrome
Aplastic Anemia - Overview Who? • M = F • 3 peaks: 1) Childhood 2) 15-25 years 3) >60 years What? • Aplastic anemia
and petechiae Causes ... • Improve the symptoms ... result from low blood ... Aplastic #Anemia #oncology ... #hematology #diagnosis
Posterior Reversible Encephalopathy Syndrome (PRES) Overview Clinico-Radiological Syndrome, characterized by: • Headache • Seizures • Altered mental
Etiology: • Pathophysiology ... Neurological symptoms ... Reversible course Differential ... elevated white blood ... the underlying cause
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... Presentation - Systemic Symptoms ... pulses, bruis, or blood ... Large Vessel: Blood ... #diagnosis #rheumatology
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
ingestion • B symptoms ... Workup: • Full Blood ... Immunohistochemical studies (to differentiate ... marrow biopsy - if blood ... #oncology #management
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