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Drug-Induced Acute Kidney Injury - Sites of Action Along the Nephron

#DrugInduced #AcuteKidneyInjury #AKI #Nephrology #Pathophysiology #Pharmacology
Drug-Induced Acute ... Kidney Injury - ... the Nephron #DrugInduced ... AcuteKidneyInjury #AKI #Nephrology ... Pathophysiology #Pharmacology
Medications causing Acute Kidney Injury (AKI)
Prerenal:
 • Dehydration: Diuretics
 • Altered intrarenal autoregulation: ACEIs / ARBs,
Medications causing ... Acute Kidney Injury ... #Medications #Drugs ... #pharmacology # ... differential #diagnosis
Acute Kidney Injury (AKI) - Differential Diagnosis Framework

PRE-Renal AKI:
 • Hypovolemia
 • Congestion
 • Medications
 •
Acute Kidney Injury ... (AKI) - Differential ... Congestion • Medications ... Infection-mediated, Drug-induced ... Diagnosis #nephrology
Drug Induced Kidney Injury
 • Pre-Renal: NSAIDS, CNI, ACEI/ARB, IL-2 therapy, Diuretics CAR-T therapy
 • Osmotic
Drug Induced Kidney ... @kdjhaveri #DrugInduced ... #KidneyInjury #differential ... diagnosis #algorithm #nephrology ... #Medications
Numerous drugs taken by elderly persons can affect water balance by direct action on the kidney
Numerous drugs taken ... #Diagnosis #Pharmacology ... #Hyponatremia #Medications ... #DrugInduced #List ... #Differential
Reticulocyte Production Index = (Retic %) x (Hct / 45) / Maturation Factor
The maturation factor is
deficiencies: Chronic kidney ... suppression (e.g. drugs ... Index > 3: • Acute ... Production #Index #hematology ... #anemia #differential
Simplified Approach to Acute Kidney Injury (AKI)
1) IS THIS AN EMERGENCY? 
Is there a dialysis indication
Simplified Approach to Acute ... Kidney Injury ( ... there a dialysis indication ... e.g AEIOU ) or anuria ... obstruction, Nephrotoxic drugs
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
Classification: • Acute ... permanent alopecia Differential ... lymphopenia, low PLT • Anemia ... extremities Drug ... activation and/or medications