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differential coagulation management prolonged abnormal disorders rheumatology treatment activation algorithm bruising cryofibrinogenemia dic disease disseminated hemophilia hemostasis inr intravascular macrophage
Causes of Prolonged PT (INR), Prolonged PTT • Prolonged PT (INR), Prolonged PTT • Prolonged PT
Causes of Prolonged ... PTT, Normal PT ... (INR) - Bleeding ... #Differential #Diagnosis ... #Hematology #coagulation
Von Willebrand Disease - Most common inherited bleeding disorder Clinical • Easy bruising •
disorder Clinical ... 2B) • Normal PT ... INR • Normal aPTT ... VonWillebrand #Disease #Diagnosis ... #Hematology
Differential Diagnosis for a Prolonged PT and aPTT If the PT and the aPTT are both prolonged,
Differential Diagnosis ... for a Prolonged PT ... PT and the aPTT ... #Causes #diagnosis ... #differential #hematology
Causes of Abnormal PT and/or aPTT Prolonged Prothrombin Time (PT) 1. Acquired deficiency of FVII
Causes of Abnormal ... PT and/or aPTT ... Pre-analytical cause ... #Causes #diagnosis ... #differential #hematology
Causes of Thrombocytopenia and Platelet Disorders - Differential Diagnosis and Workup History: - Prior platelet count, family
- Differential Diagnosis ... - History of bleeding ... : INR/PT, aPTT(liver ... function test, ANA (e.g ... #hematology
Hemophilia - Diagnosis and Management Diagnosis: • Consistent bleeding history (unless screening for disease in family members
mixing study (aPTT ... normal in mild cases ... ) • PT/INR & von ... hemophilia type (e.g ... Management #treatment #hematology
Disseminated Intravascular Coagulation (DIC) Overview Increased Clotting and Consumption of Clotting Factors Findings: • Bleeding • Recent history
• Prolonged PT ... organ damage Clinical ... Fibrinogen: ↓ • PT ... #Coagulation #diagnosis ... #management #hematology
Bleeding and Bruising - Disorders of Hemostasis - Differential Diagnosis Framework == Quantitative or Qualitative defect in
Bleeding and Bruising ... - Differential Diagnosis ... discern these causes ... #Differential #Diagnosis ... #Hematology
Macrophage Activation Syndrome (MAS) Classified among the secondary or acquired forms of haemophagocytic lymphohistiocytosis (sHLH) What? A subset of
Fever is the main clinical ... Hypofibrinogenemia • ↑ PT ... ↑ PTT • ↑ Fibrin ... Activation #Syndrome #Diagnosis ... #Management #Hematology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
cryoglobulin (CG ... Paradoxical spontaneous bleeding ... : • + Clinical ... cryoglobulins • Negative causes ... hematology
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