8 results
CNS Manifestations of Systemic Lupus Erythematosus (SLE)

Clinical Manifestations: Demyelinating Syndrome, Headache, Movement disorders, Seizure disorders, Aseptic
CNS Manifestations ... , Seizure disorders ... Disease, PRES Pathophysiology ... Lumbar Puncture, EEG ... Treatment:
Eosinophil Disorders Testing Algorithm
INDICATIONS FOR TESTING:
 • Peripheral blood eosinophilia/hypereosinophilia uncovered incidentally during medical evaluation or
Eosinophil Disorders ... workup for specific symptoms ... glucocorticoid treatment ... (eg, skin or esophageal ... Differential #diagnosis #hematology
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... Dehydration • Symptoms ... Lysis Syndrome: • Pathophysiology ... unless worrisome EKG ... diagnosis #management #hematology
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
• Malignancy (e.g ... . hematologic) ... (e.g. thyroid disease ... and CNS • Headache ... Induced Lupus: • Symptoms
Essential Thrombocythemia (ET)
ET is a chronic myeloproliferative neoplasm. Most cases are related to mutations that affect
When present, symptoms ... • Thrombosis (e.g ... hemoproliferative disorder ... Thrombocythemia #ET #hematology ... diagnosis #management #hematology
Hemophagocytic Lymphohistiocytosis (HLH)

High mortality without prompt recognition and management. HLH is a critical diagnostic consideration in
Common Signs and Symptoms ... Pathophysiology ... Treatment Approach ... malignancy, autoimmune disorder ... Diagnosis #Management #Hematology
TAFRO

TAFRO syndrome was first described in 2010, standing for:
- Thrombocytopenia
- Anasarca
- Fever
- Reticulin fibrosis
- Organomegaly

TAFRO syndrome
cell lymphoma Pathophysiology ... histopathologic changes in LNs ... and the systemic symptoms ... Hypoalbuminemia Treatment ... diagnosis #management #rheumatology
Langerhans Cell Histiocytosis (LCH)

Granulomatous Lesions comprising langerin-positive histiocytes and an inflammatory infiltrate can arise in virtually
LCH is a rare disorder ... some ethnicities (e.g ... • Pulmonary Symptoms ... CNS involvement: ... TREATMENT OPTIONS