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Nephron - Diuretic Sites of Action

Source Text: https://www.sciencedirect.com/book/9780323449427/critical-care-nephrology#book-info

#Nephron #Diuretics #Site #Action #Location #Nephrology #Pathophysiology #Pharmacology
Nephron - Diuretic ... Sites of Action ... #Site #Action # ... Location #Nephrology ... #Pathophysiology
Hormones Acting on the Nephron - Diuretics and Their Site of Action
 1) Acetazolamide
 2) Osmotic
Hormones Acting ... Their Site of Action ... spironolactone) #Pathophysiology ... #Nephrology #Nephron ... #Locations #SiteOfAction
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
Nephron Pathophysiology ... of Action Diuretics ... ) Loop agents (eg ... Adenosine #Nephron #Pathophysiology ... #Action #nephrology
ACEI or ARB Initiation
Hyperkalemia:
 - Review concurrent drugs
 - Moderate potassium Intake
 - Consider: diuretics, sodium
ACEI or ARB Initiation ... - Consider: diuretics ... blcaibonate, Gl cation ... concomitant medications (e.g ... ., diuretics, NSAIDs
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
Diuretics and Agents ... Symport (Loop Diuretics ... the Nonspecific Cation ... Postoperative abdominal distention ... #Nephrology #Pharmacology
Causes of High-anion Gap and Non-anion Gap Metabolic Acidosis
Causes of High-anion Gap Acidosis:
 • Lactic acidosis
Gap and Non-anion ... Potassium-sparing diuretics ... ACE-Is and ARBs ... Cation exchange ... diagnosis #causes #nephrology
Hyperkalemia - Diagnosis and Management - GrepMed Handbook

S/Sx: Most pts asymptomatic. Weakness, cramping, nausea, paresthesias, palpitations,
Medications: K+, ACEi ... heparinized tube) • ECG ... Exchanges K+ for cations ... (10g PO tid) - caution ... Treatment #potassium #nephrology
Scleroderma Renal Crisis (SRC)

Clinical Presentation of Scleroderma Renal Crisis:
1) Acute kidney injury
2) Abrupt onset of hypertension
3)
anemia (MAHA) Pathophysiology ... ) • Initiate ACEi ... (short-acting, ... uncontrolled with ACEi ... #rheumatology #nephrology