9 results
Hormones Acting on the Nephron - Diuretics and Their Site of Action
 1) Acetazolamide
 2) Osmotic
Hormones Acting ... and Their Site ... spironolactone) #Pathophysiology ... #Nephrology #Nephron ... #SiteOfAction #Kidney
Nephron Pathophysiology - Diuretic Sites of Action
Diuretics
1) Acetazolamide/canagliflozin
2) Osmotic agents (mannitol, urearetics)
3) Loop agents (eg, furosemide)
4)
- Diuretic Sites ... of Action Diuretics ... ) Loop agents (eg ... #Diuretics #Sites ... #Action #nephrology
Metabolic Alkalosis - Urinary Chloride Algorithm
Cl- responsive metabolic alkalosis
 • Kidney loss of Cl-
Kidney loss ... loop or thiazide diuretics ... diuretic use, Bartter ... the indicated causes ... urine #Algorithm #nephrology
Diuretics and Agents Regulating Renal Excretion

Carbonic Anhydrase Inhibitors (Acetazolamide, Dichlorphenamide)
 • Glaucoma
 • Epilepsy
 • Altitude
• Metabolic alkalosis ... stones caused by ... the Nonspecific Cation ... Postoperative abdominal distention ... #Nephrology #Pharmacology
Causes of Metabolic Alkalosis: Differential Diagnosis
ECF volume contracted: urine chloride concentration <20 meq/L
 • Gastric alkalosis:
Causes of Metabolic ... vomiting/ nasogastric suction ... thiazide-sensitive site ... Differential #Diagnosis #Causes ... #nephrology
Hypochloremia - Differential Diagnosis Algorithm

Cause - Decreased Intake:
 • Low salt in diet
 • Exclusive D5W
- Metabolic alkalosis ... RENAL LOSS: - Diuresis ... unloading • Kidney ... metabolic alkalosis ... Diagnosis #Algorithm #Pathophysiology
Causes of Secondary Hypertension - Workup and Differential Diagnosis
Approach (when evaluation should be done):
1. Severe or
, including a diuretic ... heart failure, neurologic ... disturbance, or acute kidney ... and metabolic alkalosis ... Neurologic disorders
Hepatorenal Syndrome (HRS)

Definition:
• Functional, potentially reversible kidney impairment.
• Occurs in advanced liver disease: cirrhosis, severe alcoholic
Caused by splanchnic ... No structural kidney ... Pathophysiology: ... liver insult (e.g ... Syndrome #Hepatology #Nephrology
Scleroderma Renal Crisis (SRC)

Clinical Presentation of Scleroderma Renal Crisis:
1) Acute kidney injury
2) Abrupt onset of hypertension
3)
Crisis: 1) Acute kidney ... anemia (MAHA) Pathophysiology ... Initiate ACEi (short-acting ... • Refractory cases ... #rheumatology #nephrology