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diagnosis differential rheumatology acidosis cryofibrinogenemia cryoglobulins dermatology gammopathy glomerulonephritis hematology lactate lactic mgrs monoclonal progressive rapidly renal rpgn significance skinrash
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
deposit of immune complexes ... • They can cause ... Cryoglobulins Cause ... Types: • Type ... #classification
Rapidly Progressive Glomerulonephritis (RPGN) RPGN has three primary pathophysiologic causes differentiated by immunofluorescence Immune Complex Mediated (granular staining):
pathophysiologic causes ... immunofluorescence Immune Complex ... Lupus Nephritis, Cryoglobulinemia ... Glomerulonephritis #Vasculitis ... differential #diagnosis #algorithm
Skin Ulcers by Etiology - Differential Diagnosis Algorithm Physical: • Trauma • Pressure • Radiation Vascular: • Arterial
Differential Diagnosis Algorithm ... insufficiency • Vasculitis ... Thalessemia • Cryoglobulinemia ... Viral - Herpes simplex ... #causes
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tracts Immune Complex ... tract, and often causes ... ANCA +MPO) • Cryoglobulinemic ... Low levels mixed cryoglobulinemia ... #rheumatology #classification
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis The most common causes of hyperlactatemia are usually:
Elevation, Lactic ... the patient’s complete ... Elevation Type ... Lactic #Acidosis #Elevation ... classification
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
Divided Into Two Types ... malignancies, vasculitis ... , sepsis or cryoglobulinemia ... cryoglobulins • Negative causes ... Calciphylaxis • Cryoglobulinemia
Monoclonal Gammopathy of Renal Significance (MGRS) MGRS • MGRS refers to kidney disease caused by nephrotoxic monoclonal immunoglobulins
kidney disease caused ... guide subtype classification ... formation causing vasculitis ... Types of MGRS-Associated ... immunotactoid GN, cryoglobulinemic
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