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diagnosis management symptoms signs differential nephrology pharmacology cardiology clinical algorithm endocrinology syndrome causes msk treatment ophthalmology hematology infectiousdiseases pulmonary complications
#paracetamol #paracetamoloverdose #NAC
#paracetamol #paracetamoloverdose ... #NAC
N-Acetyl Cysteine (NAC) Therapy Mechanism of Action: The non-toxic route of APAP metabolism gets saturated in
N-Acetyl Cysteine (NAC ... NAC helps replenish ... Figure 2.1 NAC has ... GSH) precursor, NAC3 ... substitute, and NAC4
Thiazide diuretics Carbonic anhydrase inhibitors (e.g., acetazolamide) Nat-Cl symport Na and HCO;- reabsorption Aldosterone antagonists (e.g., spironolactone) Nat channel (indirect effect) Loop diuretics (e.g., furosemide) Amiloride, #triamterene Nat-K+-2CF symport Na channel (direct effect) #NaCI reabsorption
acetazolamide) Nat-Cl ... symport Na and ... spironolactone) Nat ... +-2CF symport Na ... direct effect) #NaCI
Drugs that Impair Renal Potassium Excretion Decreased ENaC channel function: Amiloride, Triamterene, Pentamidine Decreased Aldosterone Synthesis: Heparin,
Decreased ENaC ... Beta-Blockers Decreased Na ... #Hyperkalemia #Pathophysiology
Gitelman Syndrome Pathophysiology Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome Pathophysiology ... cotransporter (NCC ... distal tubule. ↑ Nacl ... Gitelman #Syndrome #Pathophysiology
Thiazide induced Hyponatremia - Pathophysiology • Reduced distal delivery • Inhibition of the NCC (dilution capcity)-
Hyponatremia - Pathophysiology ... Inhibition of the NCC ... #Hyponatremia #Pathophysiology
Addictions: Pathogenesis Mesolimbic Dopaminergic Pathway: • Dopaminergic neurons in Ventral Tegmental Area (VTA) in midbrain under continuous
Nucleus Accumbens (NAc ... ) • The NAC receives ... response) • The NAC ... Drug #Addiction #Pathophysiology
Cerebral Salt Wasting vs SIADH - Pathophysiology 1) Neurological event 2) Sodium loss from tubules 3) Naturiesis →
Wasting vs SIADH - Pathophysiology ... reabsorption 5) ↓ Na ... SaltWasting #SIADH #Pathophysiology
Diagnostic criteria for Neutropenic Enterocolitis (NEC) Major Criteria: • Neutropenia (ANC <500 x 10^9 cells/L) • Bowel
Enterocolitis (NEC ... • Neutropenia (ANC ... 1min_idconsult #NEC
Diabetes Pathophysiology and Medication Targets The ominous octet is one concept that summarizes the different pathophysiologic pathways
Diabetes Pathophysiology ... the different pathophysiologic ... #Diabetes #Pathophysiology
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