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differential ana management antibody nuclear testing vasculitis abnormal arteritis arthritis atlas autoimmune beaus classification clinical cryofibrinogenemia cytoplasmic diseases fingernails gca
Antinuclear Antibody Testing - Nuclear and Cytoplasmic Patterns Nuclear Patterns: • Homogeneous pattern: -
Antinuclear Antibody ... phenomenon, SjS, cancer ... PBC, DM, other inflammatory ... #differential #diagnosis ... #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Antinuclear Antibodies ... Drug-Induced, Inflammatory ... , Interstitial Pulmonary ... #patterns #rheumatology ... #diagnosis #differential
Antinuclear Antibody Testing - Nuclear Patterns Homogeneous pattern: • SLE, SSc, AIH, JIA • dsDNA, chromatin,
Antinuclear Antibody ... phenomenon, SjS, cancer ... PBC, DM, other inflammatory ... #differential #diagnosis ... #rheumatology
Inflammatory Myopathies Dermatomyositis • Onset: Subacute • Pattern: Proximal • CK: Up to 50X ULN • Autoantibodies:
Inflammatory Myopathies ... Associated Features: Cancer-associated ... heliotrope, shawl sign ... BrighamChiefs #Inflammatory ... #comparison #rheumatology
Approach to Joint Pain - Arthritis Differential Diagnosis Framework Inflammatory Versus Noninflammatory Pain • Is it inflammatory
Arthritis Differential Diagnosis ... • Is there a pattern ... noninflammatory Signs ... weeks) Can Be Caused ... #MSK #rheumatology
Pulmonary Renal Syndromes - OnePager Summary Autoimmune ANCA vasculitis (AAV): GPA (granulomatous with polyangiitis), EGPA (eosinophilic granulomatosis
hematuria) • Inflammatory ... EGPA) • Auto-antibodies ... BNP, troponin if concern ... Goodpasture's cause ... • IF staining patterns
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
ab • RF • Antinuclear ... Hypocomplementemia • Can cause ... , INC risk PE, Pulmonary ... Nephrogenic DI Hematologic ... Sjogrens #Syndrome #Rheumatology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
(COVID-19) • Inflammatory ... thrombophlebitis, pulmonary ... Biopsy: Typical pathologic ... #rheumatology # ... hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
tract, and often causes ... Syndrome: - Ocular inflammatory ... purpura: strong sign ... : antibodies directed ... #rheumatology #
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
common systemic inflammatory ... systemic sx + signs ... Start steroids if concern ... them, but urgent rheumatology ... GCA #Temporal #Signs
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