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differential aflp hellp obstetrics pregnancy table thrombocytopenia vasculitis arteritis autoimmune capillary challenges classification common criticalcare cryofibrinogenemia cvid disease fluid gca
Thrombocytopenia and Pregnancy - TTP/HUS, HELLP Syndrome and Acute Fatty Liver of Pregnancy (AFLP) Three syndromes in
child * Severe cases ... Thrombocytopenia #TTPHUS ... AFLP #obstetrics #hematology ... #diagnosis #table ... #comparison
Clarkson’s Disease - Capillary leak syndrome Epidemiology: Roughly 150 published cases, Median age 50 years, No sex
Clarkson’s Disease ... filling +++ (risk of pulmonary ... Breillat #Clarksons ... #diagnosis #management ... timeline #treatment #rheumatology
Thrombocytopenia and Pregnancy Three syndromes in the critically ill pregnant woman who presents with coagulation defects. 1) HELLP
Pregnancy Three syndromes ... child * Severe cases ... Thrombocytopenia #Pregnancy #TTPHUS ... Obstetrics #OBGyn #Hematology ... #Diagnosis #Comparison
Common Variable Immunodeficiency (CVID) What? CVID: Immunodeficiency disorder with hypogammaglobulinemia -> increased infection risk secondary to impaired B-cell
Lymphoma or other cancers ... gastric and breast cancer ... DDX - Other causes ... hypogammaglobulinemia #immunology #hematology ... #diagnosis #management
Leukostasis vs Tumor Lysis Syndrome Leukostasis: • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
vs Tumor Lysis Syndrome ... high WBC count cause ... WBC >100k, + lab signs ... #TLS #diagnosis ... #management #hematology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
thrombophlebitis, pulmonary ... Biopsy: Typical pathologic ... Antiphospholipid syndrome ... #rheumatology # ... hematology
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
- Differential Diagnosis ... tract, and often causes ... • Cogan Syndrome ... purpura: strong sign ... #rheumatology #
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
systemic sx + signs ... Start steroids if concern ... them, but urgent rheumatology ... GCA #Temporal #Signs ... #Management
Sjogren's Syndrome Overview Epidemiology: • F > M: 9:1 • 5-6th Decades (can be any age) Autoimmune exocrinopathy multisystemic disease
Hypocomplementemia • Can cause ... , INC risk PE, Pulmonary ... Nephrogenic DI Hematologic ... #Rheumatology # ... Diagnosis #Management
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
- Differential Diagnosis ... Vasculitis Differential Diagnosis ... purpura: Strong sign ... tract, and often causes ... #Rheumatology
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