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diagnosis rheumatology dermatology management signs arteritis cryofibrinogenemia cutaneous dermatologic dermpath e1 erythematosus gca giantcell gpa granulomatosis lesions lupus manifestations polyangiitis
Adult-Onset Still's Disease Clinical triad: Fever, Arthralgia/arthritis, Skin rash ± odynophagia + Biological inflammation: Increased neutrophils, Hyperferritinemia, decreased
Clinical triad ... Arthralgia/arthritis, Skin ... fraction < 20% Differential ... hemopathies, solid cancers ... : other autoinflammatory
Dermatological semiology of Cutaneous Vasculitis Clinicopathologic correlations • Purpura, papules, pustules, necrosis: involvement of small vessels
Connective tissue disease ... EGPA • Solid cancers ... lesions #diagnosis #clinical ... manifestations #pathology ... #lesions #differential
VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) Syndrome Clinical Syndrome: • Common Clinical Features: alveolitis, ear and
nose chondritis, skin ... thromboembolic disease ... recurrent fevers, vasculitis ... • Hematologic ... myeloid cells NEJM
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Rarely dominate the clinical ... reticularis Differential ... purpura • Mixed cryoglobulinemia ... Polyangiitis #GPA #dermatology ... rash #diagnosis #rheumatology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
malignancies, vasculitis ... Cryofibrinogenemia Clinical ... Diagnosis: • + Clinical ... Biopsy: Typical pathologic ... #hematology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
) Suspect: Clinical ... 3rd Decade Skin ... permanent alopecia Differential ... leukemia • Lung cancer ... • Cervical cancer
Giant cell arteritis (GCA) Giant cell arteritis (GCA) definition: Most common systemic inflammatory vasculitis in older adults
systemic inflammatory vasculitis ... Diagnosis = clinical ... very remarkable w/differential ... in literature (NEJM ... required due to skip
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