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differential ana anca antibody antineutrophil antinuclear arterial associations autoantibodies cryofibrinogenemia cryoglobulins cutaneous dermatologic embolism erythematosus gpa granulomatosis lupus management monoclonal
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
Associated: - Microscopic ... : • Behcet Disease ... • Cogan syndrome ... #skin #dermatology ... #rheumatology #
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
Classification of ... Vasculitis Vasculitis ... granulomatosis - microscopic ... #Vasculitis #Vessels ... #Diagnosis #Rheumatology
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
c-ANCA - Vasculitis ... granulomatosis p-ANCA - Vasculitis ... #diagnosis #table ... #rheumatology # ... antibodies
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• IgA vasculitis ... Hypersensitivity vasculitis ... • Vasculitis ... #rheumatology # ... vasculitis
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
PR3-ANCA): • Microscopic ... Dx: GPA, EGPA, microscopic ... C-ANCA) pattern: antibodies ... #rheumatology # ... classification
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Leukocytoclastic vasculitis ... • Ig A vasculitis ... HCV, HBV Not Vasculitis ... #hematology #rheumatology ... #nonpalpable #dermatology
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA) Skin involvement in granulomatosis with polyangiitis (GPA) is common and
• Pauci-immune vasculitis ... : Vasculitis: ... Granulomatous vasculitis ... Polyangiitis #GPA #dermatology ... #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
cases • Sjögren syndrome ... ANCA-Associated Vasculitis ... : • Microscopic ... Renal-limited vasculitis ... #diagnosis #rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Diagnosis Framework ... Differential Diagnosis ... (PR3-ANCA)): Microscopic ... / ANCA + MPO) Cryoglobulinemic ... #Rheumatology
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
malignancies, vasculitis ... Biopsy: Typical pathologic ... Antiphospholipid syndrome ... #rheumatology # ... hematology
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