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diagnosis autoantibodies classification erythematosus sle systemic ana antinuclear cryoglobulinemia cryoglobulins mimickers myopathy patterns signs symptoms table types vasculitides
Autoantibodies and their Disease Associations ANA - Non-specific; common in SLE, autoimmune hepatitis Anti-CCP, Rheumatoid factor - RA Anti-dsDNA
Associations ANA ... c-ANCA - Vasculitis ... Microscopic polyangiitis ... #table #rheumatology ... #antibodies
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
): • Microscopic ... - Rash, arthritis ... Dx: GPA, EGPA, microscopic ... ) pattern: antibodies ... #rheumatology #
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Using fluorescence microscopy ... Positive ANA ≠ Autoimmune ... Sjögren Syndrome, Myositis ... #rheumatology #diagnosis ... #differential
Systemic Lupus Erythematosus - Diagnosis Manifestations: - Arthritis 69% - Malar rash 40% - Fever 36% -
69% - Malar rash ... anemia 4% - Myositis ... SLE-Related Auto-Antibodies ... , Cutaneous mimickers ... #rheumatology
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
permanent alopecia Differential ... • Non-autoimmune ... rheumatologic diseases ... deficiencies • Autoimmune ... Erythematosus #Diagnosis #Rheumatology
Vasculitis - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions • Mononeuritis multiplex • Hematuria, proteinuria,
Vasculitis - Differential ... Conjunctivitis, mucositis ... • Rash, arthritis ... )): Microscopic ... #Rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
diseases: - 10% ... DDX: • ANCA (Antineutrophil ... - GPA, EGPA, microscopic ... (e.g. systemic lupus ... classification #rheumatology
Autoimmune Myositis - Differential Diagnosis Framework Inflammatory Myopathies: Commonly symmetric proximal muscle weakness, no substantial muscle pain
Autoimmune Myositis ... - Differential ... Symptoms: • Gottron rash ... (also seen in association ... #rheumatology #
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