12 results
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
ANA (Antinuclear ... connective tissue disease ... Microscopic polyangiitis ... antibodies #diagnosis #rheumatology ... #diseases
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
ANA - Non-specific ... c-ANCA - Vasculitis ... granulomatosis p-ANCA ... Microscopic polyangiitis ... diagnosis #table #rheumatology
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pauci-Immune: - ANCA-positive ... , Microscopic polyangiitis ... ) - ANCA-negative ... testing: anti-ANCA ... , anti-GBM ab, ANA
Classification of Vasculitis 
Vasculitis of large vessels 
 - Arteritis temporalis (giant-cell arteritis) 
 - Takayasu
- Kawasaki disease ... small vessels - ANCA-associated ... granulomatosis - microscopic ... polyangiitis ... Vessels #Diagnosis #Rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
): • Microscopic ... Vasculitis: + MPO-ANCA ... LFT • ESR • ANA ... Dx: GPA, EGPA, microscopic ... #rheumatology #
Vasculitis Involving the Skin - Differential Diagnosis Framework

Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis
Secondary: CTD: SLE, RA
ANCA Associated ... : - Microscopic ... : • Behcet Disease ... #skin #dermatology ... #rheumatology #
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Using fluorescence microscopy ... Rheumatic Diseases ... • Rheumatic Diseases ... #patterns #rheumatology ... #diagnosis #differential
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
presentation of the disease ... GPA causes disease ... Polyarteritis nodosa • Microscopic ... #GPA #dermatology ... #rheumatology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
: ANCA Associated ... Pauci Immune (ANCA ... )): Microscopic ... No Granulomas (ANCA ... #Rheumatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Autoimmune diseases ... DDX: • ANCA (Antineutrophil ... - GPA, EGPA, microscopic ... polyangiitis ... classification #rheumatology