7 results
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
ANA (Antinuclear ... Antibody) and ANCA ... Systemic lupus erythematosus ... Microscopic polyangiitis ... #rheumatology #
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
c-ANCA - Vasculitis ... p-ANCA - Vasculitis ... Microscopic polyangiitis ... diseases #diagnosis ... #table #rheumatology
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
): • Microscopic ... Vasculitis: + MPO-ANCA ... mucositis - Rash ... Dx: GPA, EGPA, microscopic ... #rheumatology #
Classification of Vasculitis 
Vasculitis of large vessels 
 - Arteritis temporalis (giant-cell arteritis) 
 - Takayasu
small vessels - ANCA-associated ... - Wegener granulomatosis ... - microscopic ... systemic lupus erythematosus ... #Rheumatology #
Dermatologic Manifestations of Granulomatosis with Polyangiitis (GPA)

Skin involvement in granulomatosis with polyangiitis (GPA) is common and
Polyarteritis nodosa • Microscopic ... purpura • Mixed cryoglobulinemia ... • Giant cell arteritis ... #rash #diagnosis ... #rheumatology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
: ANCA Associated ... Pauci Immune (ANCA ... )): Microscopic ... No Granulomas (ANCA ... #Rheumatology
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Autoimmune diseases ... DDX: • ANCA (Antineutrophil ... - GPA, EGPA, microscopic ... systemic lupus erythematosus ... classification #rheumatology