9 results
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
ANA (Antinuclear ... Vasculitis: • ... Microscopic polyangiitis ... vasculitis - MPO ... #rheumatology #
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
Vasculitis and Vasculitides ... ): • Microscopic ... Vasculitis: + MPO-ANCA ... Dx: GPA, EGPA, microscopic ... #rheumatology #
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
c-ANCA - Vasculitis ... granulomatosis p-ANCA ... - Vasculitis, e.g ... Microscopic polyangiitis ... #table #rheumatology
Pulmonary Renal Syndrome

Definition: Diffuse alveolar hemorrhage + Glomerulonephritis
Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pauci-Immune: - ANCA-positive ... polyangiitis, Microscopic ... polyangiitis) - ANCA-negative ... testing: anti-ANCA ... , anti-GBM ab, ANA
Classification of Vasculitis 
Vasculitis of large vessels 
 - Arteritis temporalis (giant-cell arteritis) 
 - Takayasu
Vasculitis of ... small vessels - ANCA-associated ... granulomatosis - microscopic ... - systemic lupus ... #Rheumatology #
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
DDX: • ANCA (Antineutrophil ... - GPA, EGPA, microscopic ... • Vasculitis ... classification #rheumatology ... #vasculitis
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
: • ANCA-associated ... vasculitis, rheumatoid ... • Mesenteric vasculitis ... inflammation Cutaneous Vasculitis ... #Rheumatology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
rheumatic diseases ... : ANCA Associated ... Pauci Immune (ANCA ... )): Microscopic ... #Rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases

• Septic arthritis - Gram stain and culture of
Rheumatology Workup ... polarized light microscopy ... ACE level, CXR, ANCA ... #Arthritis #laboratory ... #testing #Rheumatology