10 results
Autoantibodies and their Disease Associations
ANA - Non-specific; common in SLE, autoimmune hepatitis
Anti-CCP, Rheumatoid factor - RA
Anti-dsDNA
Associations ANA ... c-ANCA - Vasculitis ... granulomatosis p-ANCA ... Microscopic polyangiitis ... #table #rheumatology
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies)
 • Systemic lupus erythematosus
   1. Anti-dsDNA
connective tissue disease ... Microscopic polyangiitis ... 90% • Anti-GBM disease ... #diagnosis #rheumatology ... #diseases
Vasculitis and Vasculitides - Differential Diagnosis Framework

When to Consider Vasculitis:
 • Purpura, ischemic skin lesions
 •
): • Microscopic ... (Granulomatous disease ... atherosclerotic disease ... Dx: GPA, EGPA, microscopic ... differential #diagnosis #rheumatology
Classification of Vasculitis 
Vasculitis of large vessels 
 - Arteritis temporalis (giant-cell arteritis) 
 - Takayasu
- Kawasaki disease ... small vessels - ANCA-associated ... granulomatosis - microscopic ... - systemic lupus ... Vessels #Diagnosis #Rheumatology
Antinuclear Antibodies (ANA)
ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Using fluorescence microscopy ... Disease! ... • Rheumatic Diseases ... : Lupus (SLE), Systemic ... #rheumatology #diagnosis
Cryoglobulinemia Summary

Cryoglobulins:
 • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Autoimmune diseases ... DDX: • ANCA (Antineutrophil ... - GPA, EGPA, microscopic ... (e.g. systemic lupus ... classification #rheumatology
Vasculitis Involving the Skin - Differential Diagnosis Framework

Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis
Secondary: CTD: SLE, RA
Secondary: CTD: SLE ... • ANCA Associated ... : - Microscopic ... : • Behcet Disease ... #rheumatology #
SLE (Systemic Lupus Erythematosus)

Suspect:
Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... Diagnosis: • ANCA-associated ... Still disease, ... diseases (i.e. ... Erythematosus #Diagnosis #Rheumatology
Vasculitis - Differential Diagnosis Framework

When to Consider Vasculitis:
• Purpura, ischemic skin lesions
• Mononeuritis multiplex
• Hematuria, proteinuria,
Systemic rheumatic diseases ... disease, drug reactions ... most important diseases ... )): Microscopic ... Differential #Diagnosis #Rheumatology
Rheumatology Workup - Laboratories Studies in Rheumatic Diseases

• Septic arthritis - Gram stain and culture of
Rheumatology Workup ... Studies in Rheumatic Diseases ... polarized light microscopy ... ACE level, CXR, ANCA ... diagnosis #testing #Rheumatology