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diagnosis classification antibodies antinuclear antibody antineutrophil aortitis cryoglobulins cutaneous dermatologic erythematosus gpa granulomatosis laboratory nephrology nonpalpable palpable patterns polyangiitis pulmonary
Vasculitis and Vasculitides - Differential Diagnosis Framework When to Consider Vasculitis: • Purpura, ischemic skin lesions •
): • Microscopic ... Vasculitis: + MPO-ANCA ... LFT • ESR • ANA ... Dx: GPA, EGPA, microscopic ... #rheumatology #
ANA (Antinuclear Antibody) and ANCA (Antineutrophil cytoplasmic antibodies) • Systemic lupus erythematosus 1. Anti-dsDNA
connective tissue disease ... Microscopic polyangiitis ... 90% • Anti-GBM disease ... antibodies #diagnosis #rheumatology ... #diseases
Vasculitis Involving the Skin - Differential Diagnosis Framework Primary: 50% Cutaneous Vasculitis: Leukocytoclastic Vasculitis Secondary: CTD: SLE, RA
ANCA Associated: ... - Microscopic ... : • Behcet Disease ... #skin #dermatology ... #rheumatology #
Classification of Vasculitis Vasculitis of large vessels - Arteritis temporalis (giant-cell arteritis) - Takayasu
- Kawasaki disease ... small vessels - ANCA-associated ... granulomatosis - microscopic ... - systemic lupus ... Vessels #Diagnosis #Rheumatology
Pulmonary Renal Syndrome Definition: Diffuse alveolar hemorrhage + Glomerulonephritis Presentation (Pulmonary and renal manifestations can occur weeks apart):
Pauci-Immune: - ANCA-positive ... polyangiitis, Microscopic ... polyangiitis) - ANCA-negative ... disease, Cryoglobulinemia ... testing: anti-ANCA
Aortitis - Differential Diagnosis Framework Non-Infectious Aortitis: • Vasculitides: Giant Cell Arteritis (GCA), Takayasu's arteritis, Cogan's Syndrome,
polychondritis, Behcet's Disease ... Nodosa (PAN), ANCA ... ) • Rheumatic Diseases ... : IgG4-Related Disease ... #Diagnosis #rheumatology
Antinuclear Antibodies (ANA) ANA or Anti-NucIear Antibody refers to antibodies against antigens in the nucleus → like
Using fluorescence microscopy ... Disease! ... : Lupus (SLE), Systemic ... #patterns #rheumatology ... #diagnosis #differential
SLE (Systemic Lupus Erythematosus) Suspect: Clinical evidence of (fatigue, rash, photosensitivity, inflammatory arthritis, weight loss, and fever) and
SLE (Systemic Lupus ... findings (ANA, ... Diagnosis: • ANCA-associated ... Serositis Labs: • ANA ... Erythematosus #Diagnosis #Rheumatology
Cryoglobulinemia Summary Cryoglobulins: • Cryoglobulins are Igs in the serum that precipitate in vitro at temperatures below
• Autoimmune diseases ... DDX: • ANCA (Antineutrophil ... - GPA, EGPA, microscopic ... (e.g. systemic lupus ... classification #rheumatology
Purpura - Differential Diagnosis Framework Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
- Bone marrow disease ... (MIXED) • ANCA ... #Diagnosis #hematology ... #rheumatology # ... #nonpalpable #dermatology
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