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liver algorithm lfts transaminitis bilirubin chemistry cholestatic classification congenital dili druginduced enlarged enzymes gastroenterology hepatitis hepatocellular hodgkins hyperbilirubinemia inherited interpretation
Cryofibrinogenemia Summary Cryofibrinogenemia Epidemiology: • 40-70 years with a modest female predominance Cryofibrinogenemia: • The precipitation of a
cryoglobulinemia Associated Disorders ... cryoglobulins • Negative causes ... Biopsy: Typical pathologic ... #diagnosis #rheumatology ... #hematology
Causes of Splenomegaly - Differential Diagnosis Algorithm Infectious • Bacterial • Viral (EBV) • Parasitic • Fungal Congestive
- Differential ... Hepatic, Portal, ... Myeloproliferative disorders ... Felty's Disease • Serum ... #Causes #Hematology
Liver Enzymes (LFTs) - Causes of Hepatocellular and Cholestatic Liver Injury Hepatocellular Liver Injury • AST/ALT elevation
Enzymes (LFTs) - Causes ... more specific for hepatic ... pathology (low ... #differential # ... hepatology
Drug Induced Liver Injury (DILI) - Stepwise Diagnosis Algorithm DILI suspicion Features toxic aetiology: Skin involvement, Kidney injury,
DILI) - Stepwise Diagnosis ... for alternative causes ... vascular disorder ... (e.g. ascites), ... #hepatology
Inherited Non-hemolytic Disorders of Hyperbilirubinemia == Disorders of Conjugation == Gilbert Syndrome: • 5-10% of the population
hemolysis or liver injury ... after birth with serum ... and stress may cause ... • Defect in hepatic ... Congenital #bilirubin #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
- Differential ... Diagnosis Algorithm ... Vascular Causes ... : • Hepatic vein ... #hepatology
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
LFTs R-value: Serum ... replaced by non-hepatic ... liver #chemistry #diagnosis ... #differential # ... Hepatology #transaminitis
Hodgkin's Lymphoma Overview Hodgkin's lymphoma (HL) is an uncommon hematological malignancy arising from mature B cells. It
• Autoimmune disorders ... • Increased Serum ... • Increased Serum ... Immunohistochemical studies (to differentiate ... classification #hematology
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