18 results
Thrombotic Microangiopathy - TTP VS HUS

Big picture points : Often hard to differentiate the two entities,
Thrombotic Microangiopathy ... Often hard to differentiate ... #Thrombotic ... #Comparison #Diagnosis ... #Table #Hematology
Thrombotic Microangiopathies - Primary Thrombotic Microangiopathy (TMA) - Differential Diagnosis Table

 • Thrombotic Thrombocytopenic Purpura (TTP)
Microangiopathy ... Diagnosis Table ... Thrombocytopenic ... Purpura (TTP) ... #TMA #hematology
Algorithm for workup of thrombocytopenia based on observation of the peripheral blood film. 
TTP/HUS indicates thrombotic
TTP/HUS indicates ... thrombotic thrombocytopenic ... , Hematology 2012 ... #Differential # ... Algorithm #Thrombocytopenia
Treatment of Thrombotic Thrombocytopenic Purpura (TTP)
Diagnosis of TTP:
 • Rare and severe, ADAMTS13 deficiency
 • Autoimmune
Thrombocytopenic ... Diagnosis of TTP ... microangiopathy ... Thrombotic #Thrombocytopenic ... #hematology
Thrombotic Microangiopathy - TMAs
1. Not all MAHAs are due to TMAs but (almost) all TMAs cause
Thrombotic Microangiopathy ... triad of MAHA + thrombocytopenia ... Cr>2.3 & platelets ... #TMAs #hematology ... #diagnosis #ttp
Thrombocytopenia - Differential Diagnosis Algorithm

Decreased production:
 • Bone marrow suppression
 • Bone marrow failure
 • Bone
Thrombocytopenia ... Diagnosis Algorithm ... Connective tissue disorders ... Diagnosis #Algorithm ... #hematology #platelets
Approach to Thrombotic Microangiopathy (TMA) - Differential Diagnosis and Management Algorithm

Suspected TMA: Unexplained thrombocytopenia + MAHA
Approach to Thrombotic ... Microangiopathy ... (TMA) - Differential ... TMA: Unexplained thrombocytopenia ... #Algorithm #hematology
Purpura - Differential Diagnosis Framework

Non-blanchable, dark red to purple, hemorrhagic skin lesions that result from leakage
Purpura - Differential ... Diagnosis Framework ... disease - DIC/TTP ... #Diagnosis #hematology ... #nonpalpable #dermatology
Diagnostic Framework for Hemolysis - Intravascular vs Extravascular Causes
Intravascular Hemolysis:
 • Mechanical Trauma (Microangiopathic hemolytic anemia):
: Thrombotic thrombocytopenic ... purpura (TTP), ... lymphoproliferative disorders ... Extravascular #Causes #differential ... #diagnosis #hematology
Platelet disorders and Aggregometry
Glanzmann Thrombasthenia
 • Defective aggregation to all agonists except ristocetin
 • Normal platelet,
Platelet disorders ... Gplb receptor • Thrombcytopenia ... #disorders #hematology ... #hemepath #differential ... #diagnosis #Aggregometry