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Acromegaly - Diagnosis and Management Summary - GrepMed Handbook 

Clinical Presentation: 
 • Classic Acromegaly: frontal
and Management ... malignancy Pathophysiology ... Differential Diagnosis ... #Endocrinology ... #Treatment #Pathophysiology
Hemophagocytic Lymphohistiocytosis (HLH)
Pathophysiology: Triggering factor (infection,...)→Activation of CD8 T cells (IFN-y) → Excessive activation of macrophages
Lymphohistiocytosis (HLH) Pathophysiology ... Triggering factor (infection ... →Activation of CD8 ... Lymphohistiocytosis #diagnosis #management ... treatment #summary #rheumatology
Bandemia Overview

Normal: < 1%
Clinically significant: > 10%

Band neutrophils are slightly less mature than segmented neutrophils and
Neutrophil (Normal) Differential ... superior indicator of infection ... #Bandemia #differential ... neutrophil #WBC #CBC ... #hematology #pathophysiology
Differentiation Syndrome in APML
Epidemiology:
 • Incidence: common in APL (2-48% depending on the study)
 • Triggers:
ATRA treatment Pathophysiology ... initiation • Differential ... Diagnosis: Infection ... APML #diagnosis #management ... #hematology #oncology
Lung Abscess - Diagnosis and Management Summary

Lung Abscess Etiology:
 • Necrosis of lung parenchyma by a
polymicrobial infection ... Lung Abscess Pathophysiology ... Diagnosis: • CBC ... Lung Abscess Differential ... Abscess #pulmonary #differential