19 results
Cholestatic Liver Disease: Primary Biliary Cirrhosis vs Primary Sclerosing Cholangitis

#pathophysiology #pbc #psc #hepatology #comparison
Cholestatic Liver ... Primary Biliary Cirrhosis ... Cholangitis #pathophysiology ... #pbc #psc #hepatology
Abnormal Liver Function Tests - Differential Diagnosis Algorithm for Transaminitis
Hepatocellular Pattern (ALT or AST > ALP):
Abnormal Liver Function ... Ducts - PBC ... Congenital, Others, Cirrhosis ... Burak @kwburak #LFTs ... #diagnosis #hepatology
Primary Biliary Cirrhosis - Diagnosis Algorithm
Symptoms: Fatigue, Pruritus, Right upper quadrant discomfort
Signs: Jaundice, Xanthelasmata, Hepatomegaly
Associated history:
Primary Biliary Cirrhosis ... - Diagnosis Algorithm ... Liver biopsy findings ... #Biliary #Cirrhosis ... #hepatology
Elevated Liver Enzymes - Differential Diagnosis Algorithm
Severe ALT > 15x ULN
 • Viral
 • Drugs/Toxins
 •
Elevated Liver Enzymes ... Bile Ducts • PSC ... Infiltrative • Cirrhosis ... • Others #LFTs ... #Hepatology #LiverEnzymes
Primary Biliary Cirrhosis (PBC) - Summary

PBC Epidemiology:
 • Female:Male 9:1
 • Common European descent
 • Age:
Primary Biliary Cirrhosis ... Pathophysiology ... /Liver failure ... or higher • Liver ... diagnosis #workup #hepatology
Acute Liver Injury - Differential Diagnosis Algorithm

Vascular Causes of Acute Liver Injury: 
 • Hepatic vein:
Differential Diagnosis Algorithm ... Autoimmune hepatitis, PBC ... hepatitis: < 1 • Cirrhosis ... differential #diagnosis #algorithm ... #hepatology
Hepatocellular Carcinoma (HCC) in Cirrhosis - Management Algorithm

Very early (0) - Single <2 cm, Preserved liver
Carcinoma (HCC) in Cirrhosis ... - Management Algorithm ... Carcinoma #HCC #Cirrhosis ... #Management #Algorithm ... #hepatology
Liver Chemistries - Interpretation of LFTs

R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP)
 • R >
Interpretation of LFTs ... hepatitis: < 1 • Cirrhosis ... • LDH: Heart, RBC ... #differential #Hepatology ... transaminitis #LFTs
Diagnosis and Management of Idiosyncratic Drug-induced Liver Injury (DILI)

DILI Types:
 • Intrinsic - predictable, dose dependent
Diagnosis and Management ... Chronic - ongoing ↑ LFTs ... differential #Diagnosis #Management ... gastroenterology #algorithm ... gastroenterology #hepatology
The 6 C’s of Primary Sclerosing Cholangitis (PSC)
PSC is a chronic, cholestatic, immune-mediated disease characterized by
CIRRHOSIS - ... indications for liver ... disease management ... Cholangitis #diagnosis #management ... #summary #Hepatology