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32 results

Metformin Associated Lactic Acidosis (MALA)

Pathophysiology of MALA
- Metformin interferes with the activity of the

Associated Lactic Acidosis ... (MALA) Pathophysiology ... acidosis including ... LacticAcidosis #Toxicity #Toxicology ... #Diagnosis #Management

Colchicine Toxicity
Naturally-occurring plant alkaloid [Autumn Crocus and Glory Lilly]
2-24 hrs
• Severe GI distress

Renal failure • Metabolic ... acidosis • ARDS ... Colchicine #Toxicity #Toxicology ... #Symptoms #Signs

Refeeding Syndrome: Pathogenesis and clinical findings

Patients at Risk of Refeeding Syndrome:
- Little or no nutritional

• Incr Glucose Metabolism ... - Metabolic ... Acidosis • Shift ... #diagnosis #pathophysiology ... #symptoms #signs

Propofol-Related Infusion Syndrome (PRIS)

Diagnosis is based on a constellation of clinical suspicion and biochemical signs including:

and biochemical signs ... Hyperlactatemia • Metabolic ... acidosis • Rhabdomyolysis ... PRIS #Diagnosis #Management ... Pharmacology #Toxicity #Toxicology

Salicylate Toxicity - Diagnosis and Management

Consider if:
1) Patient is hot and altered
2) You see tachypnea with

show anion-gap metabolic ... acidosis 4) Presentation ... Labs: Anion-Gap Metabolic ... Acidosis, Respiratory ... Aspirin #Toxicity #Toxicology

Clinical manifestations of acute liver failure

Brain:
Hepatic encephalopathy,
Cerebral edema,
Intracranial hypertension,

Hepatorenal syndrome ... Hepatoadrenal syndrome ... Liver: Loss of metabolic ... Coagulopathy, Lactic acidosis ... liver #failure #Signs

Acute Iron Poisoning

There are five classically described phases of toxicity:
Gastrointestinal phase (~6 hours post-ingestion)
-

acidosis (12-48 ... - Anion gap metabolic ... acidosis with both ... Poisoning #Toxicity #Toxicology ... #Diagnosis #Management

Management of Serotonin Syndrome
Identify and stop all serotoninergic medications
• Avoid inadvertent Rx of serotoninergic meds

Management of Serotonin ... Syndrome Identify ... normalize vital signs ... #Management #treatment ... #toxicology

Ketosis Disorders
Ketone bodies are a normal metabolic energy source. Excessive unregulated production of ketones, often accompanied

bodies are a normal metabolic ... by an anion gap acidosis ... fatty acid (FA) metabolism ... of re-feeding syndrome ... differential #diagnosis #management

$Hypochloremia - Differential Diagnosis Algorithm Cause - Decreased Intake: • Low salt in diet • Exclusive D5W$

Excessive vomiting - Metabolic ... - Gitelman SIGNS ... increase may cause metabolic ... acidosis - Cl ... Diagnosis #Algorithm #Pathophysiology

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