14 results
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
(MALA) Pathophysiology ... use in cellular metabolism ... via anaerobic metabolism ... also includes symptoms ... of metabolic acidosis
 Acute Iron Poisoning

There are five classically described phases of toxicity:
Gastrointestinal phase (~6 hours post-ingestion)
 -
post-ingestion) - Symptom ... deterioration Shock and metabolic ... acidosis (12-48 ... - Anion gap metabolic ... acidosis with both
Refeeding Syndrome: Pathogenesis and clinical findings

Patients at Risk of Refeeding Syndrome:
 - Little or no nutritional
• Incr Glucose Metabolism ... Syndrome - Metabolic ... Acidosis • Shift ... Constipation - MSK ... #symptoms #signs
Metabolic Acidosis with Anion Gap - KILU Mnemonic

K - Ketoacidosis
	• DKA
		- With normal glucose, ask if
Metabolic Acidosis ... normal glucose, ask ... (rare in lit), iron ... Mnemonic #AnionGap #Metabolic ... #Acidosis #diagnosis
Acute Fatty Liver of Pregnancy (AFLP)
Pathophysiology:
 • Defect in fetal free fatty acid metabolism products →
free fatty acid metabolism ... Intermediate fatty acid metabolism ... postpartum): • Initial symptoms ... Monitor and Treat Complications ... Liver #Pregnancy #hepatology
Stages of Iron Toxicity

Iron overdose can cause an anion gap metabolic acidosis. Severe cases can lead
cause an anion gap metabolic ... acidosis. ... Recovery from GI symptoms ... Ill Shock and metabolic ... acidosisMetabolic
Refeeding Syndrome Overview

What Is It?
	• Electrolyte/fluid shifts caused by initiation of nutrition in severely malnourished patient.
from hormonal and metabolic ... severe clinical complications ... overload) Other Symptoms ... Differential #Diagnosis #Pathophysiology
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings
 • Note: in DKA, body K+ is lost
Due to neuronal metabolism ... Signs/Symptoms/Complications ... DiabeticKetoacidosis #DKA #pathophysiology
Heat Illnesses and Heat Stroke - Differential Diagnosis Framework

Heat Cramps:
 • Muscle pain or spasm -
• Labs: - Metabolic ... acidosis - Rhabdomyolysis ... Collapse: • Pathophysiology ... Syncope • Signs/Symptoms ... - Mild lactic acidosis
There are similarities and differences between these 3 conditions which all carry treatment implications. Each mimic
carry treatment implications ... ), acidosis is very ... also have Lactic Acidosis ... The metabolism of ... present with severe acidosis