23 results
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
Associated Lactic Acidosis ... (MALA) Pathophysiology ... use in cellular metabolism ... acidosis including ... LacticAcidosis #Toxicity #Toxicology
Acid Base Disorders - Blood Gas Interpretation

Steps for Blood Gas Interpretation: 
1. Acidemia or Alkalemia? 
2.
Acidosis ↑ ↑ ... Acidosis <0.4 ... Metabolic acidosis ... D-lactate (short bowel syndrome ... MDaniyalHashmi1 #AcidBase
Salicylate Toxicity - Diagnosis and Management

Consider if:
1) Patient is hot and altered
2) You see tachypnea with
show anion-gap metabolic ... acidosis 4) Presentation ... Acidosis, Respiratory ... Aspirin #Toxicity #Toxicology ... diagnosis #management #Treatment
Refeeding Syndrome: Pathogenesis and clinical findings

Patients at Risk of Refeeding Syndrome:
 - Little or no nutritional
Refeeding Syndrome ... • Incr Glucose Metabolism ... - Metabolic ... Acidosis • Shift ... #diagnosis #pathophysiology
Acquired Disorders of Reduced Bone Strength: Pathogenesis
 • Hyperparathyroidism
 • Vitamin D deficiency
 • Malabsorption syndromes
Acquired Disorders ... Malabsorption syndromes ... • Chronic metabolic ... acidosis • Physical ... #BoneStrength #pathophysiology
Rhabdomyolysis - Differential Diagnosis and Management Summary

Trauma:
 • Immobilization, Crush iniury, Compartment syndrome, Electrical injury
Exertional:
 •
iniury, Compartment syndrome ... , Heat stroke, Metabolic ... Neuroleptic malignant syndrome ... Dermatomyositis) AKI - Pathophysiology ... oxidative iniury Treatment
Hyperkalemia - Differential Diagnosis Framework

PseudoHyperkalemia:
 • Lab error
 • Traumatic venipuncture
 • Hemolysis, thrombocytosis, leukocytosis
 •
- Tumor lysis syndrome ... infusions) - Metabolic ... acidosis - Hyperkalemia ... Hypoaldosteronism • Acquired
Propofol-Related Infusion Syndrome (PRIS)

Diagnosis is based on a constellation of clinical suspicion and biochemical signs including:
Propofol-Related Infusion Syndrome ... Hyperlactatemia • Metabolic ... acidosis • Rhabdomyolysis ... Related #Infusion #Syndrome ... Pharmacology #Toxicity #Toxicology
Refeeding Syndrome Overview

What Is It?
	• Electrolyte/fluid shifts caused by initiation of nutrition in severely malnourished patient.
Refeeding Syndrome ... from hormonal and metabolic ... • Nephrotic syndrome ... hyperparathyroidism Treatment ... Differential #Diagnosis #Pathophysiology
Causes of Lactate Elevation, Lactic Acidosis - Differential Diagnosis

The most common causes of hyperlactatemia are usually:
impairment of cellular metabolism ... sweat) - its metabolism ... perfusion - shock->treatments ... before beginning treatment ... - Compartment syndrome