11 results
Colchicine Toxicity 
Naturally-occurring plant alkaloid [Autumn Crocus and Glory Lilly]
2-24 hrs 
 • Severe GI distress
Colchicine Toxicity ... Renal failure • Metabolic ... acidosis • ARDS ... still alive) #Colchicine ... #Toxicity #Toxicology
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
Associated Lactic Acidosis ... (MALA) Pathophysiology ... use in cellular metabolism ... acidosis including ... LacticAcidosis #Toxicity
Salicylate Toxicity - Diagnosis and Management

Consider if:
1) Patient is hot and altered
2) You see tachypnea with
Salicylate Toxicity ... show anion-gap metabolic ... acidosis 4) Presentation ... Acidosis, Respiratory ... diagnosis #management #Treatment
Phases of Colchicine Toxicity
 - Early Phase (0-24h) 
 - Multi-organ failure Phase (1-7 days)
Phases of Colchicine ... Toxicity - Early ... Hemolysis, DIC Metabolic ... : Metabolic acidosis ... #Toxicity #Toxicology
Intercalated cells response to Metabolic Alkalosis and Metabolic Acidosis
 • Type B Intercalated Cell - "B"
cells response to Metabolic ... Alkalosis and Metabolic ... Acidosis • Type ... Muner Mohamed @MunerMohamed1 ... Intercalated #cells #pathophysiology
There are similarities and differences between these 3 conditions which all carry treatment implications. Each mimic
which all carry treatment ... Ketosis (SK), acidosis ... The metabolism of ... algorithm #management #treatment ... #criticalcare #foamed
The crusade against “Ab”Normal Saline continues.  This is a non-physiologic fluid that can harm our
inevitably leads to Metabolic ... Acidosis. ... Metabolic Acidosis ... #foamed #criticalcare ... management #diagnosis #treatment
Methotrexate Renal Toxicity 
Prevention:
 • Alkalinize the urine, keep urine ph >7
 • Start pre-treatment 12
Methotrexate Renal Toxicity ... • Start pre-treatment ... fluids till you see metabolic ... alkalosis • Forced ... Methotrexate #Renal #Toxicity
Malignant Hyperthermia Crisis - Guidelines for Crises in Anaesthesia
Unexplained increase in ETCO2 AND tachycardia AND increased
❹ Call for MH treatment ... COMPLICATIONS AND OUTLINE TREATMENTS ... amiodarone/metoprolol Metabolic ... acidosis: hyperventilate ... Myoglobinaemia: forced
Posterior Reversible Encephalopathy Syndrome (PRES) Overview

Clinico-Radiological Syndrome, characterized by:
 • Headache
 • Seizures
 • Altered mental
Etiology: • Pathophysiology ... Medication/Drug toxicity ... , Metabolic disturbance ... epilepticus Treatment ... underlying cause • Treatment