12 results
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
Associated Lactic Acidosis ... (MALA) Pathophysiology ... acidosis including ... LacticAcidosis #Toxicity ... #Toxicology #Diagnosis
Salicylate Toxicity - Diagnosis and Management

Consider if:
1) Patient is hot and altered
2) You see tachypnea with
Salicylate Toxicity ... show anion-gap metabolic ... acidosis 4) Presentation ... #Toxicology #diagnosis ... #management #Treatment
Intercalated cells response to Metabolic Alkalosis and Metabolic Acidosis
 • Type B Intercalated Cell - "B"
Alkalosis and Metabolic ... Acidosis • Type ... Muner Mohamed @MunerMohamed1 ... Intercalated #cells #pathophysiology ... #nephrology
Clozapine Toxicology
Clozapine is an atypical antipsychotic most often reserved for use in patients who have treatment-resistant
Clozapine Toxicology ... patients who have treatment-resistant ... - Metabolism - ... #Toxicity #Diagnosis ... #Pharmacology
Propofol-Related Infusion Syndrome (PRIS)

Diagnosis is based on a constellation of clinical suspicion and biochemical signs including:
Hyperlactatemia • Metabolic ... acidosis • Rhabdomyolysis ... Diagnosis #Management #Pharmacology ... #Toxicity #Toxicology
Salicylate Poisoning - Toxicology

Acute toxicity = vomiting, tachypnea, tinnitus, diaphoresis, and lethargy. This may progress to
Salicylate Poisoning - Toxicology ... Acute toxicity ... alkalosis and metabolic ... acidosis. ... #Toxicology #Pharmacology
Citrate Anticoagulation Toxicity

Hypernatremia (HyperNa):
 - Citrate solutions may have ↑ sodium content and should be paired
Anticoagulation Toxicity ... think citrate toxicity ... Acidosis: - Citrate ... Metabolic alkalosis ... #toxicology #nephrology
Phases of Colchicine Toxicity
 - Early Phase (0-24h) 
 - Multi-organ failure Phase (1-7 days)
of Colchicine Toxicity ... : Metabolic acidosis ... #Colchicine #Toxicity ... #Toxicology #Phases ... #Pharmacology #
Methotrexate Renal Toxicity 
Prevention:
 • Alkalinize the urine, keep urine ph >7
 • Start pre-treatment 12
Methotrexate Renal Toxicity ... fluids till you see metabolic ... alkalosis • Forced ... Methotrexate #Renal #Toxicity ... #nephrology
The crusade against “Ab”Normal Saline continues.  This is a non-physiologic fluid that can harm our
Acidosis. ... Metabolic Acidosis ... #foamed #criticalcare ... management #diagnosis #treatment ... #pharmacology #