37 results
High Anion Gap Metabolic Acidosis (HAGMA) - Differential Diagnosis - GOLDMARK

Glycols - ethylene and propylene glycol
Oxoproline
High Anion Gap Metabolic ... Acidosis (HAGMA ... with short bowel syndrome ... Aspirin - salicylate toxicity ... #Acidosis #HAGMA
Metformin Associated Lactic Acidosis (MALA) 

Pathophysiology of MALA
 - Metformin interferes with the activity of the
Associated Lactic Acidosis ... (MALA) Pathophysiology ... also includes symptoms ... of metabolic acidosis ... LacticAcidosis #Toxicity
Salicylate Toxicity - Diagnosis and Management

Consider if:
1) Patient is hot and altered
2) You see tachypnea with
Salicylate Toxicity ... show anion-gap metabolic ... acidosis 4) Presentation ... ingestion/exposure Symptoms ... diagnosis #management #Treatment
Colchicine Toxicity 
Naturally-occurring plant alkaloid [Autumn Crocus and Glory Lilly]
2-24 hrs 
 • Severe GI distress
Colchicine Toxicity ... Renal failure • Metabolic ... acidosis • ARDS ... #Colchicine #Toxicity ... #Toxicology #Symptoms
Refeeding Syndrome: Pathogenesis and clinical findings

Patients at Risk of Refeeding Syndrome:
 - Little or no nutritional
• Incr Glucose Metabolism ... - Metabolic ... Acidosis • Shift ... #diagnosis #pathophysiology ... #symptoms #signs
 Acute Iron Poisoning

There are five classically described phases of toxicity:
Gastrointestinal phase (~6 hours post-ingestion)
 -
post-ingestion) - Symptom ... deterioration Shock and metabolic ... acidosis (12-48 ... - Anion gap metabolic ... acidosis with both
Clinical manifestations of acute liver failure 

Brain: 
Hepatic encephalopathy,  
Cerebral edema,  
Intracranial hypertension,
Hepatorenal syndrome ... Hepatoadrenal syndrome ... Liver: Loss of metabolic ... Coagulopathy, Lactic acidosis ... failure #Signs #Symptoms
Leukostasis vs Tumor Lysis Syndrome
Leukostasis:
 • Pathophysiology: Large, immature blasts and high WBC count cause hyperviscosity
Leukostasis: • Pathophysiology ... Dehydration • Symptoms ... changes, stroke symptoms ... organ damage • Treatment ... : • Pathophysiology
Statin Induced Muscle Toxicity - Summary

Clinical Presentation:
 • Elevations of serum creatine kinase with proximal myalgia
Induced Muscle Toxicity ... any time during treatment ... Guillain-Barré syndrome ... antisynthetase syndrome ... Statin #muscle #toxicity
Refeeding Syndrome Overview

What Is It?
	• Electrolyte/fluid shifts caused by initiation of nutrition in severely malnourished patient.
Refeeding Syndrome ... from hormonal and metabolic ... overload) Other Symptoms ... hyperparathyroidism Treatment ... Differential #Diagnosis #Pathophysiology