16 results
Amyotrophic Lateral Sclerosis (ALS) Summary
ALS: combination of the clinical examination finding of amyotrophy with the pathologic
lateral sclerosis Pathophysiology ... and LMN signs in ... and LMN signs to ... and LMN signs on ... EMG: LMN Signs in
Gitelman Syndrome Pathophysiology
Gitelman Syndrome is a rare autosomal recessive salt-losing tubulopathy with a prevalence of 1-
Gitelman Syndrome Pathophysiology ... delivery to distal nephron ... → Hypokalemia Metabolic ... Gitelman #Syndrome #Pathophysiology ... #nephrology #diagnosis
Weakness - Differential Diagnosis Framework

Approach To Weakness:
 • Non-neuromuscular disorder (Cardiac, pulmonary etc)
 • CNS ->
Upper Motor Neuron ... Radiation • Metabolic ... Gravis - Lack of UMN ... /LMN signs - Lack ... Hypothyroid • Metabolic
Hypothyroid Myopathy
Very common (up to 80% ) in patients with hypothyroidism
Pathophysiology:
 • T4 deficiency leads to
hypothyroidism Pathophysiology ... mitochondrial oxidative metabolism ... Hypothyroid #Myopathy #pathophysiology ... #signs #symptoms ... #endocrinology
Feedback Loop: Growth Hormone (GH)
Growth Hormone:
 • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates lipolysis Signs ... thickness) - metabolic ... #FeedbackLoop #endocrinology ... #pathophysiology
Hypochloremia - Differential Diagnosis Algorithm

Cause - Decreased Intake:
 • Low salt in diet
 • Exclusive D5W
Excessive vomiting - Metabolic ... - Gitelman SIGNS ... increase may cause metabolic ... Diagnosis #Algorithm #Pathophysiology ... #Nephrology #Chloride
Stransky's Sign on Physical Exam - Babinski Equivalent
Stransky's sign is a clinical sign in which vigorous
Stransky's Sign ... is a clinical sign ... with upper motor neuron ... PhysicalExam #clinical #neurology ... #UMN #video #Pyramidal
Stransky's Sign on Physical Exam - Babinski Equivalent
Stransky's sign is a clinical sign in which vigorous
Stransky's Sign ... is a clinical sign ... with upper motor neuron ... PhysicalExam #clinical #neurology ... #UMN #video #Pyramidal
Rossolimo's Reflex on Physical Exam - Babinski Equivalent
Rossolimo's sign is a clinical sign in which percussion
Equivalent Rossolimo's sign ... is a clinical sign ... with upper motor neuron ... PhysicalExam #clinical #neurology ... #UMN #video #Pyramidal
Spinal Cord Disorders - Differential Diagnosis Framework

Spinal cord neurological lesion:
Clinical findings:
 • Symptoms and signs below
• Symptoms and signs ... Toxic Metabolic: ... : Areflexia UMN ... plantar response LMN ... disorders #diagnosis #neurology