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diagnosis symptoms neurology acromegaly bulimianervosa cholecalciferol complications diabetes diabetic diabeticketoacidosis differential dka elevated eudka euglycemic feedbackloop gh growthhormone hemorrhage hyperparathyroidism
Vitamin D Metabolism #VitaminD #Metabolism #Pathophysiology #Endocrinology #Pathways
Vitamin D Metabolism ... #VitaminD #Metabolism ... #Pathophysiology ... #Endocrinology ... #Pathways
Vitamin D Metabolism Pathways Dr. Jamie Willows @jamiekwillows #VitaminD #Metabolism #Pathways #pathophysiology #endocrinology
Vitamin D Metabolism ... Pathways Dr. ... #Metabolism #Pathways ... #pathophysiology ... #endocrinology
Vitamin D Metabolism Fat-soluble vitamin Sources: dermal synthesis and food (dairy products, fish) Active form: calcitriol (1,25-OH Vitamin D) Main
Vitamin D Metabolism ... Fat-soluble vitamin ... mendesthiagob #VitaminD ... #Metabolism #endocrinology ... #pathophysiology
Steroid Synthesis Pathway (OH, hydroxy; HSD, hydroxysteroid dehydrogenase; DHEA, dehydroepiandrosterone; pink, common enzymes affecting CAH, purple –
Steroid Synthesis Pathway ... Steroid #Synthesis #Pathway ... #metabolism #pathophysiology ... #endocrinology
Feedback Loop: Growth Hormone (GH) Growth Hormone: • Liver -> GHR activates JAK-STAT pathway -> Incr IGF1
activates JAK-STAT pathway ... activates lipolysis Signs ... thickness) - metabolic ... #FeedbackLoop #endocrinology ... #pathophysiology
Hyperparathyroidism - Primary vs Secondary vs Tertiary Lab Comparison: • Primary Hyperparathyroidism: ↑→PTH, ↑Calcium, ↑Vitamin D,
PTH, ↑Calcium, ↑Vitamin ... PTH, ↓→Calcium, ↓Vitamin ... Symptoms: Commonly no signs ... Hyperparathyroidism #diagnosis #endocrinology ... Secondary #Tertiary #pathophysiology
Hypothyroid Myopathy Very common (up to 80% ) in patients with hypothyroidism Pathophysiology: • T4 deficiency leads to
hypothyroidism Pathophysiology ... mitochondrial oxidative metabolism ... Hypothyroid #Myopathy #pathophysiology ... #signs #symptoms ... #endocrinology
Euglycemic Diabetic Ketoacidosis (EuDKA) SGLT2 Inhibitors Increasing Indications Significant Adverse Drug Effects Definition of EuDKA • Metabolic acidosis with pH
Definition of EuDKA • Metabolic ... level < 200 mg/dL Pathophysiology ... EuDKA #diagnosis #management ... #endocrinology
Intracranial Hemorrhage (ICH) and Increased Intracranial Pressure (ICP) - Pathophysiology ICH Management: 1. Manage Blood Pressure •
Pressure (ICP) - Pathophysiology ... ICH Management ... Warfarin: Octaplex + Vitamin ... • Increased metabolic ... #neurosurgery #management
Diabetic Ketoacidosis (DKA) - Pathogenesis and Clinical Findings • Note: in DKA, body K+ is lost
Due to neuronal metabolism ... Signs/Symptoms/Complications ... DiabeticKetoacidosis #DKA #pathophysiology ... #endocrinology
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