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diagnosis differential lfts chemistry injury tests algorithm alkphos anticoagulation astalt biliary bleed chads2 chads2vasc cholangitis comparison function hasbled hematology hepatitis
Bilirubin Metabolism - Pathophysiology • Conjugated Bilirubin • Unconjugated Bilirubin By Dr. Khushboo Gala @LouLectures #Bilirubin #Metabolism #Pathophysiology
Bilirubin Metabolism ... - Pathophysiology ... • Conjugated Bilirubin ... #Metabolism #Pathophysiology ... #hepatology #Liver
Elevated Liver Function Tests (LFTs) - Differential Diagnosis Framework Mild (<100-500): • NAFLD • Cirrhosis •
Elevated Liver Function ... • NAFLD • Cirrhosis ... : • Genetic/Metabolic ... Differential #Diagnosis #hepatology ... #transaminitis
Liver Chemistry Tests - AST, ALT, Alkaline Phosphatase and Bilirubin Metabolism AST and ALT: • AST: liver
Phosphatase and Bilirubin ... Metabolism AST ... metabolism: • ... Tests #Laboratory #Metabolism ... #Hepatology #Pathophysiology
Patterns of Liver Injury Transaminase Levels: > 50x normal - Ischemic Hepatitis > 20x normal
Patterns of Liver ... CMV), Alcoholic cirrhosis ... NASH, Genetic / Metabolic ... #Injury #hepatology ... #LFTs #transaminitis
Liver Chemistries - Interpretation of LFTs R-value: Serum (ALT/ULN ALT) / (Alk phos/ULN ALP) • R >
week • Direct bilirubin ... hepatitis: < 1 • Cirrhosis ... Elevation: • Bilirubin ... #differential #Hepatology ... #transaminitis
CHA2DS2VASc vs HAS-BLED scores for stroke risk and bleed risk on anticoagulation C Congestive Heart Failure 1 H Hypertension 1 A2 Age >75 2 D Diabetes Mellitus 1 S2 Stroke,
Abnormal renal/liver ... >2.3mg/dL) 1 Liver ... (cirrhosis, bilirubin ... Anticoagulation #AFib ... #Diagnosis #Hematology
Acute Liver Injury - Differential Diagnosis Algorithm Vascular Causes of Acute Liver Injury: • Hepatic vein:
• Metabolic/Hereditary ... week • Direct bilirubin ... hepatitis: < 1 • Cirrhosis ... Elevation: • Bilirubin ... diagnosis #algorithm #hepatology
Primary Biliary Cirrhosis (PBC) - Summary PBC Epidemiology: • Female:Male 9:1 • Common European descent • Age:
65 years PBC Pathophysiology ... /Liver failure ... slightly elevated • Bilirubin ... or higher • Liver ... diagnosis #workup #hepatology
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